PDF(Pubmed)
Abstract：
Investigations into human longevity are increasingly focusing on healthspan enhancement, not just lifespan extension. Lifestyle modifications and nutritional choices, including food supplements, can significantly affect aging and general health. Phytochemicals in centenarians\' diets, such as those found in Timut pepper, a Nepalese spice with various medicinal properties, may contribute to their longevity. Similarly, Sichuan pepper, a related species, has demonstrated anti-inflammatory and neuroprotective activities. With the broader purpose of uncovering a novel treatment to address aging and its comorbidities, this study aims to investigate the potential lifespan- and healthspan-promoting effects of Timut pepper using the model organism Caenorhabditis elegans. We show that Timut pepper extract extends C. elegans\' lifespan at different maintenance temperatures and increases the proportion of active nematodes in their early adulthood. In addition, we show that Timut pepper extract enhances speed and distance moved as the nematodes age. Finally, Timut pepper extract assures extracellular matrix homeostasis by slowing the age-dependent decline of collagen expression.
摘要：
对人类寿命的调查越来越关注提高健康状况，不仅仅是延长寿命。生活方式的改变和营养选择，包括食品补充剂，会显著影响衰老和整体健康。百岁老人饮食中的植物化学物质，比如在TimutPepper中发现的，一种具有各种药用特性的尼泊尔香料，可能有助于他们的长寿。同样，四川辣椒,一个相关的物种，具有抗炎和神经保护活性。更广泛的目的是发现一种新的治疗方法来解决衰老及其合并症，本研究旨在研究使用模式生物秀丽隐杆线虫的Timut辣椒的潜在寿命和健康促进作用。我们表明，Timut辣椒提取物在不同的维持温度下延长了秀丽隐杆线虫的寿命，并增加了成年早期活跃线虫的比例。此外,我们表明，随着线虫年龄的增长，Timut辣椒提取物可以提高移动的速度和距离。最后,木瓜辣椒提取物通过减缓胶原蛋白表达的年龄依赖性下降来确保细胞外基质稳态。
