PDF(Pubmed)
Abstract：
Undernutrition (UN) increases child vulnerability to illness and mortality. Caused by a low amount and/or poor quality of food intake, it impacts physical, cognitive, and social development. Modern types of food consumption have given highly processed food a higher cultural value compared to minimally processed food.
OBJECTIVE: The objective of this study was to evaluate the effect on growth, metabolism, physical activity (PA), memory, inflammation, and toxicity of an enriched black corn chip (BC) made with endemic ingredients on post-weaned UN mice.
METHODS: A chip was made with a mixture of black corn, fava beans, amaranth, and nopal cactus. To probe the effects of UN, UN was induced in 3wo post-weaned male C57Bl/6j mice through a low-protein diet (LPD-50% of the regular requirement of protein) for 3w. Then, the BC was introduced to the animals\' diet (17%) for 5w; murinometric parameters were measured, as were postprandial glucose response, PA, and short-term memory. Histological analysis was conducted on the liver and kidneys to measure toxicity. Gene expression related to energy balance, thermogenesis, and inflammation was measured in adipose and hypothalamic tissues.
RESULTS: Treatment with the BC significantly improved mouse growth, even with a low protein intake, as evidenced by a significant increase in body weight, tail length, cerebral growth, memory improvement, physical activation, normalized energy expenditure (thermogenesis), and orexigenic peptides (AGRP and NPY). It decreased anorexigenic peptides (POMC), and there was no tissue toxicity.
CONCLUSIONS: BC treatment, even with persistent low protein intake, is a promising strategy against UN, as it showed efficacy in correcting growth deficiency, cognitive impairment, and metabolic problems linked to treatment by adjusting energy expenditure, which led to the promotion of energy intake and regulation of thermogenesis, all by using low-cost, accessible, and endemic ingredients.
OBJECTIVE: The objective of this study was to evaluate the effect on growth, metabolism, physical activity (PA), memory, inflammation, and toxicity of an enriched black corn chip (BC) made with endemic ingredients on post-weaned UN mice.
METHODS: A chip was made with a mixture of black corn, fava beans, amaranth, and nopal cactus. To probe the effects of UN, UN was induced in 3wo post-weaned male C57Bl/6j mice through a low-protein diet (LPD-50% of the regular requirement of protein) for 3w. Then, the BC was introduced to the animals\' diet (17%) for 5w; murinometric parameters were measured, as were postprandial glucose response, PA, and short-term memory. Histological analysis was conducted on the liver and kidneys to measure toxicity. Gene expression related to energy balance, thermogenesis, and inflammation was measured in adipose and hypothalamic tissues.
RESULTS: Treatment with the BC significantly improved mouse growth, even with a low protein intake, as evidenced by a significant increase in body weight, tail length, cerebral growth, memory improvement, physical activation, normalized energy expenditure (thermogenesis), and orexigenic peptides (AGRP and NPY). It decreased anorexigenic peptides (POMC), and there was no tissue toxicity.
CONCLUSIONS: BC treatment, even with persistent low protein intake, is a promising strategy against UN, as it showed efficacy in correcting growth deficiency, cognitive impairment, and metabolic problems linked to treatment by adjusting energy expenditure, which led to the promotion of energy intake and regulation of thermogenesis, all by using low-cost, accessible, and endemic ingredients.
摘要：
营养不良（UN）增加了儿童对疾病和死亡率的脆弱性。由食物摄入量低和/或质量差引起，它影响身体，认知，和社会发展。与最低加工食品相比，现代类型的食品消费赋予了高度加工食品更高的文化价值。
目的：本研究的目的是评估对生长的影响，新陈代谢，身体活动（PA），记忆,炎症,和用地方性成分制成的富含黑色玉米片（BC）对断奶后的UN小鼠的毒性。
方法：用黑玉米的混合物制成芯片，蚕豆,栀子,还有Nopal仙人掌.为了探究联合国的影响，通过低蛋白饮食（LPD-常规蛋白质需求的50％）3w，在断奶后的3wo雄性C57Bl/6j小鼠中诱导了UN。然后，将BC引入动物饮食（17％）5w;测量murinometric参数，餐后葡萄糖反应也是如此，PA,和短期记忆。对肝脏和肾脏进行组织学分析以测量毒性。与能量平衡相关的基因表达，产热,在脂肪和下丘脑组织中测量炎症。
结果：用BC处理可显著改善小鼠生长，即使蛋白质摄入量低，体重显著增加，尾部长度,大脑生长,记忆力改善,物理激活,归一化能量消耗(产热)，和食欲肽（AGRP和NPY）。它减少了厌食肽（POMC），并且没有组织毒性。
结论：BC治疗，即使持续低蛋白摄入，是一个有希望的对抗联合国的战略，因为它显示了纠正生长不足的功效，认知障碍，以及通过调整能量消耗与治疗相关的代谢问题，这导致了能量摄入的促进和产热的调节，所有通过使用低成本，可访问,和特有的成分。
目的：本研究的目的是评估对生长的影响，新陈代谢，身体活动（PA），记忆,炎症,和用地方性成分制成的富含黑色玉米片（BC）对断奶后的UN小鼠的毒性。
方法：用黑玉米的混合物制成芯片，蚕豆,栀子,还有Nopal仙人掌.为了探究联合国的影响，通过低蛋白饮食（LPD-常规蛋白质需求的50％）3w，在断奶后的3wo雄性C57Bl/6j小鼠中诱导了UN。然后，将BC引入动物饮食（17％）5w;测量murinometric参数，餐后葡萄糖反应也是如此，PA,和短期记忆。对肝脏和肾脏进行组织学分析以测量毒性。与能量平衡相关的基因表达，产热,在脂肪和下丘脑组织中测量炎症。
结果：用BC处理可显著改善小鼠生长，即使蛋白质摄入量低，体重显著增加，尾部长度,大脑生长,记忆力改善,物理激活,归一化能量消耗(产热)，和食欲肽（AGRP和NPY）。它减少了厌食肽（POMC），并且没有组织毒性。
结论：BC治疗，即使持续低蛋白摄入，是一个有希望的对抗联合国的战略，因为它显示了纠正生长不足的功效，认知障碍，以及通过调整能量消耗与治疗相关的代谢问题，这导致了能量摄入的促进和产热的调节，所有通过使用低成本，可访问,和特有的成分。
