目的:本研究旨在比较非活动性炎症性肠病(IBD)患者在大学门诊治疗方案中通过选定的公式预测的测量和估计的静息代谢率(RMR)。
方法:72例成人(≥20岁)IBD患者(45例克罗恩病CD)通过间接量热法测量了RMR(mRMR),并通过预测方程(坎宁安,亨利,Anjosetal.,和Marra等人。).通过DXA评估身体组成。计算绝对偏差(估计-mRMR)和%偏差(偏差/mRMR)。在Bland&Altman方法中,协议被评估为协议限制(LoA)。
结果:年龄没有差异,患有CD(5414.2±1023.7kJ/天)和溃疡性结肠炎(5443.9±1008.9kJ/天)的个体之间的身体组成和mRMR。在方程式中,只有Anjos等人。特定于人口的方程(-52.1[642.0]kJ/天,P=0.493;LoA:-1311;1206kJ/d)准确估计RMR。Marra等人的方程。产生的%偏差最高(24.1±14.8%)。Bland&Altman图显示,所有方程式的LoA范围相对相似。在简单的回归分析中,与包含BM的模型(DC为R2=0.35,UC为0.65)相比,FFM模型的决定系数更高(UC为DC为0.74,R2=0.51).
结论:在分析的方程中,只有Anjos等人。对门诊非活动性IBD患者的RMR进行了准确估计。然而,在个人层面应用时要谨慎,由于广泛观察到的LoA。
OBJECTIVE: The present study aimed to compare measured and estimated resting metabolic rate (RMR) predicted by selected equations in patients with nonactive inflammatory bowel disease (IBD) on an outpatient university clinic regimen.
METHODS: Seventy-two adult (≥20 years) IBD patients (45 with Crohn\'s disease-CD) had RMR measured (mRMR) by indirect calorimetry and also estimated by predictive equations (Cunningham, Henry, Anjos et al., and Marra et al.). Body composition was assessed by DXA. Absolute Bias (estimated - mRMR) and % Bias (Bias/mRMR) were calculated. Agreement was assessed as the limit of agreement (LoA) in the Bland & Altman approach.
RESULTS: There was no difference in age, body composition and mRMR between individuals with CD (5414.2 ± 1023.7 kJ/day) and ulcerative colitis (5443.9 ± 1008.9 kJ/day). Among the equations, only the Anjos et al.\'s population-specific equation (-52.1 [642.0] kJ/day, P = 0.493; LoA: -1311; 1206 kJ/d) accurately estimated RMR. The equations of Marra et al. produced the highest % Bias (24.1 ± 14.8%). The Bland & Altman plots showed that the range of the LoA was relatively similar for all equations. In the simple regression analysis, the model with FFM resulted in a higher coefficient of determination (R2 = 0.51 for DC 0.74 for UC) compared to the model that included BM (R2 = 0.35 for DC and 0.65 for UC).
CONCLUSIONS: Among the equations analyzed, only Anjos et al.\'s accurately estimated RMR in outpatients with nonactive IBD. However, caution is advised when applying it at the individual level, due to the wide observed LoA.