PDF(Pubmed)
Abstract：
Antibiotic resistance, a known global health challenge, involves the flow of bacteria and their genes among animals, humans, and their surrounding environment. It occurs when bacteria evolve and become less responsive to the drugs designated to kill them, making infections harder to treat. Despite several obstacles preventing the spread of genes and bacteria, pathogens regularly acquire novel resistance factors from other species, which reduces their ability to prevent and treat such bacterial infections. This issue requires coordinated efforts in healthcare, research, and public awareness to address its impact on human health worldwide. This review outlines how recent advances in gene editing technology, especially CRISPR/Cas9, unveil a breakthrough in combating antibiotic resistance. Our focus will remain on the relationship between CRISPR/cas9 and its impact on antibiotic resistance and its related infections. Moreover, the prospects of this new advanced research and the challenges of adopting these technologies against infections will be outlined by exploring its different derivatives and discussing their advantages and limitations over others, thereby providing a corresponding reference for the control and prevention of the spread of antibiotic resistance.
摘要：
抗生素耐药性,一个已知的全球健康挑战，涉及细菌及其基因在动物中的流动，人类,和他们周围的环境。当细菌进化并对指定杀死它们的药物反应减弱时，就会发生这种情况，使感染难以治疗。尽管有几个障碍阻止了基因和细菌的传播，病原体定期从其他物种获得新的抗性因子，这降低了他们预防和治疗这种细菌感染的能力。这个问题需要医疗保健方面的协调努力，研究,和公众意识，以解决其对全球人类健康的影响。这篇综述概述了基因编辑技术的最新进展，特别是CRISPR/Cas9，揭示了对抗抗生素耐药性的突破。我们的重点仍然是CRISPR/cas9及其对抗生素耐药性及其相关感染的影响之间的关系。此外，将通过探索其不同的衍生物并讨论其相对于其他衍生物的优势和局限性来概述这项新的先进研究的前景以及采用这些技术对抗感染的挑战，从而为控制和预防抗生素耐药性的传播提供相应的参考。
