Abstract：
Two new aromatic compounds, namely gastupdin A (1), and gastupdin B (2), together with three known compounds, arundin(3), phomosines B (4) and monocillin IV (5), were isolated from the aerial parts of Gastrodia elata Blume. The structures of the new compounds were confirmed through spectral analyses including NMR, HR-ESI-MS, ECD, UV, and IR. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine-induced cell death in Human Neuroblastoma Cells, with curcumin as the positive control, however, the activity of all compounds was weaker than the positive control, showing no significant activity.
摘要：
两种新的芳香族化合物，即gastupdinA(1)，和胃病B（2），连同三种已知的化合物，arundin(3),phomosinesB(4)andmonocillinIV(5),是从天麻的地上部分分离出来的。通过包括NMR在内的光谱分析证实了新化合物的结构。HR-ESI-MS,ECD,UV,和IR。评估所有分离的化合物对人类神经母细胞瘤细胞中6-羟基多巴胺诱导的细胞死亡的神经保护作用。以姜黄素为阳性对照,然而,所有化合物的活性均弱于阳性对照，没有明显的活动。
