Abstract:
Two new aromatic compounds, namely gastupdin A (1), and gastupdin B (2), together with three known compounds, arundin(3), phomosines B (4) and monocillin IV (5), were isolated from the aerial parts of Gastrodia elata Blume. The structures of the new compounds were confirmed through spectral analyses including NMR, HR-ESI-MS, ECD, UV, and IR. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine-induced cell death in Human Neuroblastoma Cells, with curcumin as the positive control, however, the activity of all compounds was weaker than the positive control, showing no significant activity.
摘要:
两种新的芳香族化合物,即gastupdinA(1),和胃病B(2),连同三种已知的化合物,arundin(3),phomosinesB(4)andmonocillinIV(5),是从天麻的地上部分分离出来的。通过包括NMR在内的光谱分析证实了新化合物的结构。HR-ESI-MS,ECD,UV,和IR。评估所有分离的化合物对人类神经母细胞瘤细胞中6-羟基多巴胺诱导的细胞死亡的神经保护作用。以姜黄素为阳性对照,然而,所有化合物的活性均弱于阳性对照,没有明显的活动。