PDF(Pubmed)
Abstract：
Cancer exhibits heterogeneity that enables adaptability and remains grand challenges for effective treatment. Chemotherapy is a validated and critically important strategy for the treatment of cancer, but the emergence of multidrug resistance which may lead to recurrence of disease or even death is a major hurdle for successful chemotherapy. Azoles and sulfonamides are important anticancer pharmacophores, and azole-sulfonamide hybrids have the potential to simultaneously act on dual/multiple targets in cancer cells, holding great promise to overcome drug resistance. This review outlines the current scenario of azole-sulfonamide hybrids with the anticancer potential, and the structure-activity relationships as well as mechanisms of action are also discussed, covering articles published from 2020 onward.
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[Box: see text].
摘要：
癌症表现出具有适应性的异质性，并且仍然是有效治疗的巨大挑战。化疗是一种经过验证和至关重要的癌症治疗策略，但是可能导致疾病复发甚至死亡的多药耐药性的出现是成功化疗的主要障碍。唑类和磺胺类是重要的抗癌药效，和唑-磺酰胺杂种具有同时作用于癌细胞中的双重/多重靶标的潜力，拥有克服抗药性的巨大希望。这篇综述概述了具有抗癌潜力的唑-磺酰胺杂种的当前情况，并讨论了结构-活动关系和作用机制，涵盖2020年以来发表的文章。
[方框：见正文]。
[方框：见正文]。
