%0 Journal Article
%T Recent development of azole-sulfonamide hybrids with the anticancer potential.
%A Zhao C
%A Liu Y
%A Cui Z
%J Future Med Chem
%V 16
%N 12
%D 2024
%M 38989985
%F 4.767
%R 10.1080/17568919.2024.2351291
%X Cancer exhibits heterogeneity that enables adaptability and remains grand challenges for effective treatment. Chemotherapy is a validated and critically important strategy for the treatment of cancer, but the emergence of multidrug resistance which may lead to recurrence of disease or even death is a major hurdle for successful chemotherapy. Azoles and sulfonamides are important anticancer pharmacophores, and azole-sulfonamide hybrids have the potential to simultaneously act on dual/multiple targets in cancer cells, holding great promise to overcome drug resistance. This review outlines the current scenario of azole-sulfonamide hybrids with the anticancer potential, and the structure-activity relationships as well as mechanisms of action are also discussed, covering articles published from 2020 onward.<BR>[Box: see text].