{Reference Type}: Journal Article
{Title}: Recent development of azole-sulfonamide hybrids with the anticancer potential.
{Author}: Zhao C;Liu Y;Cui Z;
{Journal}: Future Med Chem
{Volume}: 16
{Issue}: 12
{Year}: 2024
{Factor}: 4.767
{DOI}: 10.1080/17568919.2024.2351291
{Abstract}: Cancer exhibits heterogeneity that enables adaptability and remains grand challenges for effective treatment. Chemotherapy is a validated and critically important strategy for the treatment of cancer, but the emergence of multidrug resistance which may lead to recurrence of disease or even death is a major hurdle for successful chemotherapy. Azoles and sulfonamides are important anticancer pharmacophores, and azole-sulfonamide hybrids have the potential to simultaneously act on dual/multiple targets in cancer cells, holding great promise to overcome drug resistance. This review outlines the current scenario of azole-sulfonamide hybrids with the anticancer potential, and the structure-activity relationships as well as mechanisms of action are also discussed, covering articles published from 2020 onward.<BR>[Box: see text].