Abstract：
Quercetin is a natural flavonoid with various pharmacological actions such as anti-inflammatory, antioxidant, antimicrobial, anticancer, antiviral, antidiabetic, cardioprotective, neuroprotective, and antiviral activities. Looking at these enormous potentials, researchers have explored how they can be used to manage numerous cancers. It\'s been studied for cancer management due to its anti-angiogenesis, anti-metastatic, and antiproliferative mechanisms. Despite having these proven pharmacological activities, the clinical use of quercetin is limited due to its first-- pass metabolism, poor solubility, and bioavailability. To address these shortcomings, researchers have fabricated various nanocarriers-based formulations to fight cancer. The present review overshadows the pharmacological potential, mechanisms, and application of nanoformulations against different cancers.
摘要：
槲皮素是一种天然类黄酮，具有多种药理作用，如抗炎，抗氧化剂，抗菌，抗癌，抗病毒，抗糖尿病药,心脏保护,神经保护,和抗病毒活性。看看这些巨大的潜力，研究人员已经探索了如何使用它们来管理许多癌症。由于它的抗血管生成，它已经被研究用于癌症管理，抗转移性，和抗增殖机制。尽管有这些被证实的药理活性，由于槲皮素的首过代谢，其临床应用受到限制，溶解性差，和生物利用度。为了解决这些缺点，研究人员制造了各种基于纳米载体的配方来对抗癌症。本综述掩盖了药理学潜力，机制,以及纳米制剂对不同癌症的应用。
