Abstract:
Quercetin is a natural flavonoid with various pharmacological actions such as anti-inflammatory, antioxidant, antimicrobial, anticancer, antiviral, antidiabetic, cardioprotective, neuroprotective, and antiviral activities. Looking at these enormous potentials, researchers have explored how they can be used to manage numerous cancers. It\'s been studied for cancer management due to its anti-angiogenesis, anti-metastatic, and antiproliferative mechanisms. Despite having these proven pharmacological activities, the clinical use of quercetin is limited due to its first-- pass metabolism, poor solubility, and bioavailability. To address these shortcomings, researchers have fabricated various nanocarriers-based formulations to fight cancer. The present review overshadows the pharmacological potential, mechanisms, and application of nanoformulations against different cancers.
摘要:
槲皮素是一种天然类黄酮,具有多种药理作用,如抗炎,抗氧化剂,抗菌,抗癌,抗病毒,抗糖尿病药,心脏保护,神经保护,和抗病毒活性。看看这些巨大的潜力,研究人员已经探索了如何使用它们来管理许多癌症。由于它的抗血管生成,它已经被研究用于癌症管理,抗转移性,和抗增殖机制。尽管有这些被证实的药理活性,由于槲皮素的首过代谢,其临床应用受到限制,溶解性差,和生物利用度。为了解决这些缺点,研究人员制造了各种基于纳米载体的配方来对抗癌症。本综述掩盖了药理学潜力,机制,以及纳米制剂对不同癌症的应用。