柑橘类水果中存在的生物活性化合物在肿瘤学中获得了更广泛的接受。许多研究已经破译了柚皮素在人类和动物研究中的抗氧化和抗癌潜力。柚皮素(NGE)可能抑制癌症进展,从而改善癌症患者的健康。柚皮素的多效性抗癌特性包括抑制生长因子和细胞因子的合成,抑制细胞周期,以及几种细胞信号通路的修饰。作为草药,柚皮素具有显著的药理特性,如抗炎,抗氧化剂,神经保护,保肝,和抗癌活性。用纯柚皮素治疗后致癌物失活,负载柚皮素的纳米粒子,通过体外和体内研究数据证明了柚皮素与抗癌药物的联合。这些研究包括结肠癌,肺肿瘤,乳腺癌,白血病和淋巴瘤,胰腺癌,前列腺肿瘤,口腔鳞状细胞癌,肝癌,脑肿瘤,皮肤癌,宫颈癌和卵巢癌,膀胱肿瘤,胃癌,和骨肉瘤.柚皮素对炎症相关过程的影响,凋亡,扩散,血管生成,转移,和乳腺癌的侵袭在这篇叙述性综述中,以及其开发新型安全抗癌药物的潜力。
The bioactive compounds present in citrus fruits are gaining broader acceptance in oncology. Numerous studies have deciphered naringenin\'s antioxidant and anticancer potential in human and animal studies. Naringenin (NGE) potentially suppresses cancer progression, thereby improving the health of cancer patients. The pleiotropic anticancer properties of naringenin include inhibition of the synthesis of growth factors and cytokines, inhibition of the cell cycle, and modification of several cellular signaling pathways. As an herbal remedy, naringenin has significant pharmacological properties, such as anti-inflammatory, antioxidant, neuroprotective, hepatoprotective, and anti-cancer activities. The inactivation of carcinogens following treatment with pure naringenin, naringenin-loaded nanoparticles, and naringenin combined with anti-cancer agents was demonstrated by data in vitro and in vivo studies. These studies included colon cancer, lung neoplasms, breast cancer, leukemia and lymphoma, pancreatic cancer, prostate tumors, oral squamous cell carcinoma, liver cancer, brain tumors, skin cancer, cervical and ovarian cancers, bladder neoplasms, gastric cancer, and osteosarcoma. The effects of naringenin on processes related to inflammation, apoptosis, proliferation, angiogenesis, metastasis, and invasion in breast cancer are covered in this narrative review, along with its potential to develop novel and secure anticancer medications.