PDF(Pubmed)
Abstract：
The development of neural circuits has long-lasting effects on brain function, yet our understanding of early circuit development in humans remains limited. Here, periodic EEG power features and aperiodic components were examined from longitudinal EEGs collected from 592 healthy 2-44 month-old infants, revealing age-dependent nonlinear changes suggestive of distinct milestones in early brain maturation. Developmental changes in periodic peaks include (1) the presence and then absence of a 9-10 Hz alpha peak between 2-6 months, (2) nonlinear changes in high beta peaks (20-30 Hz) between 4-18 months, and (3) the emergence of a low beta peak (12-20 Hz) in some infants after six months of age. We hypothesized that the emergence of the low beta peak may reflect maturation of thalamocortical network development. Infant anesthesia studies observe that GABA-modulating anesthetics do not induce thalamocortical mediated frontal alpha coherence until 10-12 months of age. Using a small cohort of infants (n = 23) with EEG before and during GABA-modulating anesthesia, we provide preliminary evidence that infants with a low beta peak have higher anesthesia-induced alpha coherence compared to those without a low beta peak.
摘要：
神经回路的发育对大脑功能有长期的影响，然而，我们对人类早期电路发展的理解仍然有限。这里,从592名2-44个月大的健康婴儿的纵向脑电图中检查了周期性脑电图功率特征和非周期性成分，揭示年龄相关的非线性变化，暗示早期大脑成熟的不同里程碑。周期性峰值的发展变化包括（1）在2-6个月之间存在和不存在9-10Hzα峰值，（2）4-18个月之间高β峰（20-30Hz）的非线性变化，和(3)在6个月后的一些婴儿中出现低β峰(12-20Hz)。我们假设低β峰的出现可能反映了丘脑皮质网络发育的成熟。婴儿麻醉研究观察到，GABA调节麻醉药直到10-12月龄才诱导丘脑皮质介导的额叶α相干性。使用一组婴儿（n=23）在GABA调节麻醉之前和期间进行EEG，我们提供的初步证据表明,与没有低β峰的婴儿相比,低β峰的婴儿具有更高的麻醉诱导的α相干性.
