目的:我们旨在通过比较临床不对称患者受累程度较高(MA)和受累程度较低(LA)的丘脑底核(STN)的活性,建立帕金森病(PD)的特异性生物标志物。
方法:我们记录了深部脑刺激手术期间STN的单个单位活动和局部场电位(LFP)。神经元放电模式和放电率,以及单细胞和LFP的振荡特征,进行了分析。
结果:我们观察到不规则爆发和暂停爆发的比例存在显著差异,但不是补品神经元,在半球之间。暂停爆发神经元的振荡与相应半体的运动迟缓和僵硬评分显着相关。源自MASTN的LFP在12-15Hz具有更大的功率。
结论:我们的结果提供了证据,表明停顿时间延长的单位比例增加可能与PD有关。我们还推测,它们中的一些可能在与运动减退症状有关的α-β范围内获得节律性,长期疾病,或者两者兼而有之。
结论:我们的发现强调了STN的特定振荡特征之间的关系,丘脑底停顿爆发单位和PD病理生理学占优势。
OBJECTIVE: We aimed to establish specific biomarkers of Parkinson\'s disease (PD) by comparing activity of more affected (MA) and less affected (LA) subthalamic nucleus (STN) of patients with prominent clinical asymmetry.
METHODS: We recorded single unit activity and local field potentials (LFP) of the STN during deep brain stimulation surgeries. Neuronal firing patterns and discharge rate, as well as oscillatory features of both single cells and LFP, were analyzed.
RESULTS: We observed notable differences in proportions of irregular-burst and pause-burst, but not tonic neurons, between the hemispheres. Oscillations of pause-burst neurons correlated significantly with the bradykinesia and rigidity scores of the corresponding hemibody. LFP derived from MA STN featured greater power in 12-15 Hz.
CONCLUSIONS: Our results provide evidence that the increased proportion of units with prolonged pauses may be associated with PD. We also speculate that some of them may gain rhythmicity in the alpha-beta range in relation to hypokinetic symptoms, long-term disease, or both.
CONCLUSIONS: Our findings highlight the relation between specific oscillatory features of the STN, predominance of subthalamic pause-burst units and PD pathophysiology.