通过去除抑制性聚 ADP - 核糖标记 , PARG 对于 Pol θ 介导的 DNA 末端连接至关重要。
Mesh : Humans Poly (ADP-Ribose) Polymerase-1 / metabolism genetics DNA Polymerase theta DNA End-Joining Repair DNA-Directed DNA Polymerase / metabolism DNA Breaks, Double-Stranded Poly Adenosine Diphosphate Ribose / metabolism DNA Damage Animals DNA-Binding Proteins / metabolism genetics DNA / metabolism genetics HEK293 Cells Poly ADP Ribosylation Poly(ADP-ribose) Polymerases / metabolism genetics Carrier Proteins Glycoside Hydrolases Nuclear Proteins
来 源:
DOI:10.1038/s41467-024-50158-7
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