Abstract：
Autoreactive lymphocytes that infiltrate the pancreatic islet environment and target β cells are primary drivers of type 1 diabetes. In this issue of Immunity, Srivastava et al.1 examine the role of the islet microenvironment in autoimmunity and find that the scavenging receptor CXCL16 on islet-resident macrophages uptakes oxidized low-density lipoproteins and promotes the differentiation and survival of infiltrating pathogenic CD8+ T cells.
摘要：
渗透胰岛环境和靶向β细胞的自身反应性淋巴细胞是1型糖尿病的主要驱动因素。在本期的豁免权中,Srivastava等1研究了胰岛微环境在自身免疫中的作用，发现胰岛常驻巨噬细胞上的清除受体CXCL16吸收氧化的低密度脂蛋白，并促进浸润性致病性CD8T细胞的分化和存活。
