{Reference Type}: Journal Article
{Title}: Scavengers in islets fuel diabetic autoimmunity.
{Author}: Moon JY;Gallagher KA;
{Journal}: Immunity
{Volume}: 57
{Issue}: 7
{Year}: 2024 Jul 9
{Factor}: 43.474
{DOI}: 10.1016/j.immuni.2024.06.008
{Abstract}: Autoreactive lymphocytes that infiltrate the pancreatic islet environment and target β cells are primary drivers of type 1 diabetes. In this issue of Immunity, Srivastava et al.1 examine the role of the islet microenvironment in autoimmunity and find that the scavenging receptor CXCL16 on islet-resident macrophages uptakes oxidized low-density lipoproteins and promotes the differentiation and survival of infiltrating pathogenic CD8+ T cells.