%0 Journal Article
%T Scavengers in islets fuel diabetic autoimmunity.
%A Moon JY
%A Gallagher KA
%J Immunity
%V 57
%N 7
%D 2024 Jul 9
%M 38986438
%F 43.474
%R 10.1016/j.immuni.2024.06.008
%X Autoreactive lymphocytes that infiltrate the pancreatic islet environment and target β cells are primary drivers of type 1 diabetes. In this issue of Immunity, Srivastava et al.1 examine the role of the islet microenvironment in autoimmunity and find that the scavenging receptor CXCL16 on islet-resident macrophages uptakes oxidized low-density lipoproteins and promotes the differentiation and survival of infiltrating pathogenic CD8+ T cells.