■从1型糖尿病治疗中引入连续血糖监测(CGM),特别是它与胰岛素泵的整合,人们一直在寻求描述最佳血糖控制的新参数.截至2019年达成共识,动态血糖谱(AGP)已成为标准,时间范围(TIR)成为代谢控制评估的基本参数。然而,随着技术的进步,新参数,如血糖风险指数(GRI),已被引入和临床应用。因此,探索传统参数和新参数之间的关系以全面理解代谢控制是当务之急。
■这项研究于2023年1月至7月在斯普斯卡巴尼亚卢卡共和国大学医院儿科诊所进行。参与者是随机选择的,纳入标准规定年龄大于8岁,1型糖尿病持续时间超过2年。所有参与者都被要求在接下来的三个月(90天)内使用传感器增强的胰岛素泵。不管以前的使用,激活了suspend-before-low选项。
■在35名参与者中,30完成研究,14人(46.7%)为男性。受试者的平均年龄为14.90±2.88岁,糖尿病的平均病程为7.83±4.76年。在90天的时间里,HbA1c平均上升至7.31%。分析显示TIR(β=-0.771)和GRI(β=0.651)对HbA1c有显著影响。此外,GRI和TIR高度相关(β=-0.953)。
■动态血糖谱(AGP)产生的新参数可以帮助临床医生创建患者代谢控制与HbA1c水平相关的完整图像。此外,GRI是一个数学定制的参数,包含动态葡萄糖分布的所有成分,并与实验室测量的HbA1c和TIR具有很强的相关性.GRI可能成为常规临床实践中评估和管理患者的有价值的统计参数。
UNASSIGNED: From the introduction of continuous glucose monitoring (CGM) in treatments of type 1 diabetes, particularly its integration with insulin pumps, there has been a quest for new parameters that describe optimal glycemic control. As of the consensus reached in 2019, the ambulatory glucose profile (AGP) has become the standard, with time in range (TIR) emerging as a fundamental parameter for metabolic control assessment. However, with technological advancements, new parameters, such as the glycemia risk index (GRI), have been introduced and clinically utilized. Therefore, exploring the relationships between traditional and novel parameters to understand metabolic control comprehensively is imperative.
UNASSIGNED: This study was conducted at the Pediatric Clinic of the University Hospital of the Republic of Srpska Banja Luka between January and July 2023. The participants were randomly selected, with the inclusion criteria specifying an age greater than eight years and a diabetes type 1 duration exceeding two years. All participants were required to use a sensor-augmented insulin pump for the next three months (90 days), irrespective of prior use, with the suspend-before-low option activated.
UNASSIGNED: Of the 35 participants, 30 completed the study, 14 (46.7%) of whom were male. The mean age of the subjects was 14.90 ± 2.88 years, and the mean duration of diabetes was 7.83 ± 4.76 years. Over the 90-day period, HbA1c increased to an average of 7.31%. The analysis revealed significant effects of TIR (β=-0.771) and GRI (β=0.651) on HbA1c. Furthermore, GRI and TIR strongly correlated (β=-0.953).
UNASSIGNED: New parameters generated from the ambulatory glucose profile (AGP) can help clinicians create a complete picture of a patient\'s metabolic control in relation to HbA1c levels. Additionally, the GRI is a mathematically tailored parameter that incorporates all components of the ambulatory glucose profile and demonstrates strong correlations with laboratory-measured HbA1c and TIR. The GRI potentially can become a valuable statistical parameter for evaluating and managing patients in routine clinical practice.