PDF(Pubmed)
Abstract：
The highly cytotoxic macrocyclic trichothecene Isororidin A (C29H40O9) was isolated from the fungus Myrothesium verrucaria endophytic on the wild medicinal plant `Datura\' (Datura stramonium L.) and was characterized by one- (1D) and two-dimensional (2D) NMR spectroscopy. The three-dimensional structure of Isororidin A has been confirmed by X-ray crystallography at 0.81 Å resolution from crystals grown in the orthorhombic space group P212121, with one molecule per asymmetric unit. Isororidin A is the epimer of previously described (by X-ray crystallography) Roridin A at position C-13\' of the macrocyclic ring.
摘要：
从野生药用植物“曼陀罗”（曼陀罗菌）的内生真菌中分离出具有高细胞毒性的大环三端孢菌伊索洛肽A（C29H40O9），并通过一（1D）和二维（2D）NMR光谱进行表征。已通过X射线晶体学以0.81的分辨率从正交晶系P212121空间群生长的晶体中确认了依索洛定A的三维结构，每个不对称单元一个分子。依屈肽A是先前描述的(通过X射线晶体学)位于大环C-13'位的RoridinA的差向异构体。
