%0 Journal Article
%T Crystal structure of the cytotoxic macrocyclic trichothecene Isororidin A.
%A Asmaey MA
%A Kalofolias DA
%A Charavgi MD
%A Abdel-Rahim IR
%A Chrysina ED
%A Abatis D
%J Acta Crystallogr C Struct Chem
%V 80
%N 0
%D 2024 08 1
%M 38984909
%F 1.184
%R 10.1107/S2053229624006144
%X The highly cytotoxic macrocyclic trichothecene Isororidin A (C29H40O9) was isolated from the fungus Myrothesium verrucaria endophytic on the wild medicinal plant `Datura' (Datura stramonium L.) and was characterized by one- (1D) and two-dimensional (2D) NMR spectroscopy. The three-dimensional structure of Isororidin A has been confirmed by X-ray crystallography at 0.81 Å resolution from crystals grown in the orthorhombic space group P212121, with one molecule per asymmetric unit. Isororidin A is the epimer of previously described (by X-ray crystallography) Roridin A at position C-13' of the macrocyclic ring.