{Reference Type}: Journal Article
{Title}: Crystal structure of the cytotoxic macrocyclic trichothecene Isororidin A.
{Author}: Asmaey MA;Kalofolias DA;Charavgi MD;Abdel-Rahim IR;Chrysina ED;Abatis D;
{Journal}: Acta Crystallogr C Struct Chem
{Volume}: 80
{Issue}: 0
{Year}: 2024 08 1
{Factor}: 1.184
{DOI}: 10.1107/S2053229624006144
{Abstract}: The highly cytotoxic macrocyclic trichothecene Isororidin A (C29H40O9) was isolated from the fungus Myrothesium verrucaria endophytic on the wild medicinal plant `Datura' (Datura stramonium L.) and was characterized by one- (1D) and two-dimensional (2D) NMR spectroscopy. The three-dimensional structure of Isororidin A has been confirmed by X-ray crystallography at 0.81 Å resolution from crystals grown in the orthorhombic space group P212121, with one molecule per asymmetric unit. Isororidin A is the epimer of previously described (by X-ray crystallography) Roridin A at position C-13' of the macrocyclic ring.