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Abstract：
To evaluate the clinical significance of PLT, MPV, and PDW in monitoring malaria treatment efficacy and predicting disease progression. A total of 31 patients with imported malaria were selected as the observation group, while 31 non-malaria patients with fever were selected as controls. The observation group was subdivided into a complication group and a non-complication group according to the occurrence of complications during treatment. Additionally, on the 1st day (within 24 h), the 3rd day, and the 5th day following admission, a comprehensive blood routine examination, Plasmodium microscopic examination, and colloidal gold assay were conducted. The blood routine examination results were compared before and after treatment among patients in the observation group and the control group. Moreover, the study involved dynamic monitoring and analysis of the levels and variations in PLT, MPV, and PDW within both the complication group and the non-complication group. The Plasmodium density was negatively correlated with PLT before treatment. There were significant differences were observed in PLT, MPV, and PDW (P < 0.05) within the observation group before and after treatment. Notably, there were no significant alterations in red blood cell (RBC), hemoglobin (Hb), and white blood cell (WBC) counts (P > 0.05) within the observation group before and after treatment. The PLT, MPV, and PDW levels in the complication group and the non-complication group exhibited an upward trend after treatment. Further, the PLT of patients in the complication group was significantly lower than that in the non-complication group. Additionally, the PLT, MPV, and PDW levels in the complication group and the non-complication group increased gradually from the time of admission to the 3rd and 5th day of treatment. Notably, the PLT in the complication group was consistently lower than that in the non-complication group. The continuous monitoring of PLT, MPV, and PDW changes plays a crucial role in assessing malaria treatment efficacy and prognosis in these individuals.
摘要：
评价PLT的临床意义,MPV,和PDW监测疟疾治疗效果和预测疾病进展。选取31例输入性疟疾患者作为观察组,而31例非疟疾发热患者作为对照。观察组根据治疗期间并发症的发生情况分为并发症组和非并发症组。此外,在第一天（24小时内），第三天,入院后第5天,全面的血常规检查，疟原虫显微镜检查,并进行胶体金测定。比较观察组和对照组患者治疗前后的血常规检查结果。此外，这项研究涉及对PLT水平和变化的动态监测和分析，MPV,并发症组和非并发症组的PDW。治疗前疟原虫密度与PLT呈负相关。PLT有显著差异,MPV,观察组治疗前后PDW差异有统计学意义(P<0.05)。值得注意的是,红细胞（RBC）无明显改变，血红蛋白（Hb），观察组治疗前后白细胞(WBC)计数(P>0.05)。PLT,MPV,并发症组和非并发症组的PDW水平在治疗后呈上升趋势。Further,并发症组患者的PLT明显低于非并发症组。此外,PLT,MPV,并发症组和非并发症组的PDW水平从入院至治疗第3天和第5天逐渐升高。值得注意的是,并发症组的PLT始终低于非并发症组。持续监测PLT,MPV,和PDW变化在评估这些个体的疟疾治疗效果和预后中起着至关重要的作用。
