PDF(Pubmed)
Abstract：
UNASSIGNED: Monkeypox virus (MPXV) is spreading globally and nearly half of the infected people were human immunodeficiency virus (HIV) positive. Therefore, an in-depth understanding of the effects of HIV infection on the outcomes of MPXV infection is urgently needed. This study aimed to explore the clinical features, viral dynamics, and antibody response to MPXV infections in men who had sex with men (MSM) with and without HIV co-infection.
UNASSIGNED: MPXV-infected patients diagnosed by PCR were recruited in this study and were divided into MPXV and MPXV + HIV groups based on whether they were co-infected with HIV. Clinical data and samples were collected during of the hospital stay and follow up interviews. The symptoms and signs, laboratory examinations, viral shedding in various body fluids or swabs, antibody dynamics were tracked and compared between the two groups.
UNASSIGNED: A total of 41 MPXV patients were recruited through June 2023 to September 2023 in Guangzhou. The MPXV group and MPXV + HIV group comprised 20 and 21 MSM, respectively. Patients in the two groups exhibited similar clinical characteristics except for pruritus and eschar, both were significantly fewer in MPXV + HIV group than in MPXV only group. Among the 355 clinical samples collected, MPXV DNA was detected in 100% of scabs, 97.4% of skin swabs, and 92.3% of exudate swabs from lesions, while the positive rate was 87.5% from oropharyngeal swabs, 59% from saliva, 51.3% from anal swabs, 50% from feces, 30.6% from urine samples, 37.5% of semen, and 28.2% from sera. Dynamics analysis revealed that viral DNA was undetectable in most patients 20 days after symptom onset. IgM and IgG antibodies to MPXV were detected in all patients with 3-5 days earlier in the MPXV group than in the MPXV + HIV group.
UNASSIGNED: This cohort analysis based on a large outbreak among MSM in Guangzhou indicated no obvious differences in clinical symptoms, viral DNA data, but antibody responses were 3-5 days later in mpox patients with HIV infection.
UNASSIGNED: MPXV-infected patients diagnosed by PCR were recruited in this study and were divided into MPXV and MPXV + HIV groups based on whether they were co-infected with HIV. Clinical data and samples were collected during of the hospital stay and follow up interviews. The symptoms and signs, laboratory examinations, viral shedding in various body fluids or swabs, antibody dynamics were tracked and compared between the two groups.
UNASSIGNED: A total of 41 MPXV patients were recruited through June 2023 to September 2023 in Guangzhou. The MPXV group and MPXV + HIV group comprised 20 and 21 MSM, respectively. Patients in the two groups exhibited similar clinical characteristics except for pruritus and eschar, both were significantly fewer in MPXV + HIV group than in MPXV only group. Among the 355 clinical samples collected, MPXV DNA was detected in 100% of scabs, 97.4% of skin swabs, and 92.3% of exudate swabs from lesions, while the positive rate was 87.5% from oropharyngeal swabs, 59% from saliva, 51.3% from anal swabs, 50% from feces, 30.6% from urine samples, 37.5% of semen, and 28.2% from sera. Dynamics analysis revealed that viral DNA was undetectable in most patients 20 days after symptom onset. IgM and IgG antibodies to MPXV were detected in all patients with 3-5 days earlier in the MPXV group than in the MPXV + HIV group.
UNASSIGNED: This cohort analysis based on a large outbreak among MSM in Guangzhou indicated no obvious differences in clinical symptoms, viral DNA data, but antibody responses were 3-5 days later in mpox patients with HIV infection.
摘要：
■猴痘病毒（MPXV）正在全球蔓延，近一半的感染者是人类免疫缺陷病毒（HIV）阳性。因此,我们迫切需要深入了解HIV感染对MPXV感染结局的影响.本研究旨在探讨其临床特点,病毒动力学，以及在有和没有HIV共同感染的男男性行为者（MSM）中对MPXV感染的抗体反应。
■本研究招募了通过PCR诊断的MPXV感染患者，并根据他们是否与HIV共感染分为MPXV和MPXV+HIV组。在住院期间和随访访谈期间收集临床数据和样本。症状和体征，实验室检查,病毒在各种体液或拭子中脱落，追踪并比较两组间的抗体动力学.
■截至2023年6月至2023年9月，在广州共招募了41名MPXV患者。MPXV组和MPXV+HIV组包括20和21个MSM，分别。除瘙痒和焦痂外，两组患者的临床特征相似，MPXV+HIV组均显著低于仅MPXV组.在收集的355个临床样本中，在100%结痂中检测到MPXVDNA，97.4%的皮肤拭子，和92.3%的病灶渗出液拭子，口咽拭子阳性率为87.5%，59%来自唾液，51.3%来自肛门拭子，50%来自粪便，30.6%来自尿液样本，占精液的37.5％，28.2%来自血清。动力学分析显示，大多数患者在症状发作后20天无法检测到病毒DNA。MPXV组比MPXV+HIV组早3-5天，所有患者均检测到MPXV的IgM和IgG抗体。
■这项基于广州MSM大规模爆发的队列分析表明，临床症状没有明显差异，病毒DNA数据,但抗体反应是3-5天后，在感染HIV的水痘患者。
■本研究招募了通过PCR诊断的MPXV感染患者，并根据他们是否与HIV共感染分为MPXV和MPXV+HIV组。在住院期间和随访访谈期间收集临床数据和样本。症状和体征，实验室检查,病毒在各种体液或拭子中脱落，追踪并比较两组间的抗体动力学.
■截至2023年6月至2023年9月，在广州共招募了41名MPXV患者。MPXV组和MPXV+HIV组包括20和21个MSM，分别。除瘙痒和焦痂外，两组患者的临床特征相似，MPXV+HIV组均显著低于仅MPXV组.在收集的355个临床样本中，在100%结痂中检测到MPXVDNA，97.4%的皮肤拭子，和92.3%的病灶渗出液拭子，口咽拭子阳性率为87.5%，59%来自唾液，51.3%来自肛门拭子，50%来自粪便，30.6%来自尿液样本，占精液的37.5％，28.2%来自血清。动力学分析显示，大多数患者在症状发作后20天无法检测到病毒DNA。MPXV组比MPXV+HIV组早3-5天，所有患者均检测到MPXV的IgM和IgG抗体。
■这项基于广州MSM大规模爆发的队列分析表明，临床症状没有明显差异，病毒DNA数据,但抗体反应是3-5天后，在感染HIV的水痘患者。
