PDF(Pubmed)
Abstract：
UNASSIGNED: This study aimed to reveal the association between the osteoporosis self-assessment tool for Asians (OSTA) and airflow limitation (AL) in post-menopausal Japanese women.
UNASSIGNED: This cross-sectional study included 1580 participants undergoing a comprehensive health examination using spirometry and dual-energy X-ray absorptiometry. The OSTA was calculated by subtracting the age in years from the body weight (BW) in kilograms, and the result was multiplied by 0.2. The OSTA risk level was defined as low (>-1), moderate (-4 to -1), or high (<-4). AL was defined as forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) <0.7. The association between the OSTA and AL was assessed using logistic regression analysis.
UNASSIGNED: The prevalence of AL was significantly higher in the high OSTA group (15.3%) than in the low OSTA group (3.1%) (p<0.001). In multiple linear regression analysis, the OSTA was independently associated with FEV1/FVC. In logistic regression models adjusted for smoking status, alcohol consumption, current use of medication for diabetes, hyperglycemia, rheumatoid arthritis, second-hand smoke, and ovary removal showed a significantly higher risk of AL (odds ratio: 5.48; 95% confidence interval: 2.90-10.37; p<0.001) in participants with OSTA high risk than in those with OSTA low risk.
UNASSIGNED: These results suggest that the OSTA high risk indicates reduced BMD at the femoral neck and presence of AL in Japanese post-menopausal women aged ≥45 years.
UNASSIGNED: This cross-sectional study included 1580 participants undergoing a comprehensive health examination using spirometry and dual-energy X-ray absorptiometry. The OSTA was calculated by subtracting the age in years from the body weight (BW) in kilograms, and the result was multiplied by 0.2. The OSTA risk level was defined as low (>-1), moderate (-4 to -1), or high (<-4). AL was defined as forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) <0.7. The association between the OSTA and AL was assessed using logistic regression analysis.
UNASSIGNED: The prevalence of AL was significantly higher in the high OSTA group (15.3%) than in the low OSTA group (3.1%) (p<0.001). In multiple linear regression analysis, the OSTA was independently associated with FEV1/FVC. In logistic regression models adjusted for smoking status, alcohol consumption, current use of medication for diabetes, hyperglycemia, rheumatoid arthritis, second-hand smoke, and ovary removal showed a significantly higher risk of AL (odds ratio: 5.48; 95% confidence interval: 2.90-10.37; p<0.001) in participants with OSTA high risk than in those with OSTA low risk.
UNASSIGNED: These results suggest that the OSTA high risk indicates reduced BMD at the femoral neck and presence of AL in Japanese post-menopausal women aged ≥45 years.
摘要：
■本研究旨在揭示亚洲人骨质疏松症自我评估工具（OSTA）与绝经后日本女性气流受限（AL）之间的关联。
■这项横断面研究包括1580名参与者，他们使用肺活量测定法和双能X射线吸收测定法进行了全面的健康检查。OSTA是通过从以千克为单位的体重（BW）中减去年龄来计算的，结果乘以0.2。OSTA风险水平定义为低(>-1)，中等（-4到-1），或高（<-4）。AL定义为1s/用力肺活量（FEV1/FVC）<0.7的用力呼气量。使用逻辑回归分析评估OSTA和AL之间的关联。
■高OSTA组（15.3％）的AL患病率明显高于低OSTA组（3.1％）（p<0.001）。在多元线性回归分析中，OSTA与FEV1/FVC独立相关。在根据吸烟状况调整的逻辑回归模型中，酒精消费,目前使用的糖尿病药物，高血糖症,类风湿性关节炎,二手烟,和卵巢切除显示,OSTA高风险参与者的AL风险显著高于OSTA低风险参与者(比值比:5.48;95%可信区间:2.90-10.37;p<0.001).
■这些结果表明，在年龄≥45岁的日本绝经后女性中，OSTA高风险表明股骨颈处的BMD降低和AL的存在。
■这项横断面研究包括1580名参与者，他们使用肺活量测定法和双能X射线吸收测定法进行了全面的健康检查。OSTA是通过从以千克为单位的体重（BW）中减去年龄来计算的，结果乘以0.2。OSTA风险水平定义为低(>-1)，中等（-4到-1），或高（<-4）。AL定义为1s/用力肺活量（FEV1/FVC）<0.7的用力呼气量。使用逻辑回归分析评估OSTA和AL之间的关联。
■高OSTA组（15.3％）的AL患病率明显高于低OSTA组（3.1％）（p<0.001）。在多元线性回归分析中，OSTA与FEV1/FVC独立相关。在根据吸烟状况调整的逻辑回归模型中，酒精消费,目前使用的糖尿病药物，高血糖症,类风湿性关节炎,二手烟,和卵巢切除显示,OSTA高风险参与者的AL风险显著高于OSTA低风险参与者(比值比:5.48;95%可信区间:2.90-10.37;p<0.001).
■这些结果表明，在年龄≥45岁的日本绝经后女性中，OSTA高风险表明股骨颈处的BMD降低和AL的存在。
