PDF(Pubmed)
Abstract：
UNASSIGNED: Type 1 (T1D) and type 2 (T2D) diabetes lead to an aberrant metabolism of sialoglycoconjugates and elevated free serum sialic acid (FSSA) level. The present study evaluated sialidase and sialyltranferase activities in serum and some organs relevant to diabetes at early and late stages of T1D and T2D.
UNASSIGNED: Sialic acid level with sialidase and sialyltransferase activities were monitored in the serum, liver, pancreas, skeletal muscle and kidney of diabetic animals at early and late stages of the diseases.
UNASSIGNED: The FSSA and activity of sialidase in the serum were significantly increased at late stage of both T1D and T2D while sialic acid level in the liver was significantly decreased in the early and late stages of T1D and T2D, respectively. Furthermore, the activity of sialidase was significantly elevated in most of the diabetes-relevant organs while the activity of sialyltransferase remained largely unchanged. A multiple regression analysis revealed the contribution of the liver to the FSSA while pancreas and kidney contributed to the activity of sialidase in the serum.
UNASSIGNED: We concluded that the release of hepatic sialic acid in addition to pancreatic and renal sialidase might (in)directly contribute to the increased FSSA during both types of diabetes mellitus.
UNASSIGNED: Sialic acid level with sialidase and sialyltransferase activities were monitored in the serum, liver, pancreas, skeletal muscle and kidney of diabetic animals at early and late stages of the diseases.
UNASSIGNED: The FSSA and activity of sialidase in the serum were significantly increased at late stage of both T1D and T2D while sialic acid level in the liver was significantly decreased in the early and late stages of T1D and T2D, respectively. Furthermore, the activity of sialidase was significantly elevated in most of the diabetes-relevant organs while the activity of sialyltransferase remained largely unchanged. A multiple regression analysis revealed the contribution of the liver to the FSSA while pancreas and kidney contributed to the activity of sialidase in the serum.
UNASSIGNED: We concluded that the release of hepatic sialic acid in addition to pancreatic and renal sialidase might (in)directly contribute to the increased FSSA during both types of diabetes mellitus.
摘要：
■1型(T1D)和2型(T2D)糖尿病导致唾液酸糖缀合物的异常代谢和升高的游离血清唾液酸(FSSA)水平。本研究评估了T1D和T2D早期和晚期血清和与糖尿病相关的某些器官中的唾液酸酶和唾液酸转移酶活性。
■在血清中监测唾液酸水平与唾液酸酶和唾液酸转移酶活性,肝脏,胰腺,糖尿病动物在疾病早期和晚期的骨骼肌和肾脏。
■在T1D和T2D的晚期，血清中的FSSA和唾液酸酶活性均显着增加，而在T1D和T2D的早期和晚期，肝脏中的唾液酸水平显着降低，分别。此外，在大多数糖尿病相关器官中,唾液酸酶的活性显著升高,而唾液酸转移酶的活性基本保持不变.多元回归分析显示肝脏对FSSA的贡献，而胰腺和肾脏对血清中唾液酸酶的活性有贡献。
■我们得出的结论是，在两种类型的糖尿病中，除胰腺和肾脏唾液酸酶外，肝唾液酸的释放可能（在）直接导致FSSA增加。
■在血清中监测唾液酸水平与唾液酸酶和唾液酸转移酶活性,肝脏,胰腺,糖尿病动物在疾病早期和晚期的骨骼肌和肾脏。
■在T1D和T2D的晚期，血清中的FSSA和唾液酸酶活性均显着增加，而在T1D和T2D的早期和晚期，肝脏中的唾液酸水平显着降低，分别。此外，在大多数糖尿病相关器官中,唾液酸酶的活性显著升高,而唾液酸转移酶的活性基本保持不变.多元回归分析显示肝脏对FSSA的贡献，而胰腺和肾脏对血清中唾液酸酶的活性有贡献。
■我们得出的结论是，在两种类型的糖尿病中，除胰腺和肾脏唾液酸酶外，肝唾液酸的释放可能（在）直接导致FSSA增加。
