Abstract:
PURPOSE OF REVIEW: The global obesity epidemic has become a major public health concern, necessitating comprehensive research into its adverse effects on various tissues within the human body. Among these tissues, skeletal muscle has gained attention due to its susceptibility to obesity-related alterations. Mitochondria are primary source of energy production in the skeletal muscle. Healthy skeletal muscle maintains constant mitochondrial content through continuous cycle of synthesis and degradation. However, obesity has been shown to disrupt this intricate balance. This review summarizes recent findings on the impact of obesity on skeletal muscle mitochondria structure and function. In addition, we summarize the molecular mechanism of mitochondrial quality control systems and how obesity impacts these systems. RECENT FINDINGS: Recent findings show various interventions aimed at mitigating mitochondrial dysfunction in obese model, encompassing strategies including caloric restriction and various dietary compounds. Obesity has deleterious effect on skeletal muscle mitochondria by disrupting mitochondrial biogenesis and dynamics. Caloric restriction, omega-3 fatty acids, resveratrol, and other dietary compounds enhance mitochondrial function and present promising therapeutic opportunities.
摘要:
评论目的:全球肥胖流行已成为主要的公共卫生问题,需要全面研究其对人体各种组织的不利影响。在这些组织中,骨骼肌因其对肥胖相关改变的易感性而受到关注.线粒体是骨骼肌中能量产生的主要来源。健康的骨骼肌通过合成和降解的连续循环维持恒定的线粒体含量。然而,肥胖已被证明会破坏这种复杂的平衡。本文总结了肥胖对骨骼肌线粒体结构和功能影响的最新发现。此外,我们总结了线粒体质量控制系统的分子机制以及肥胖如何影响这些系统。最近发现:最近的研究结果表明,各种干预措施旨在减轻肥胖模型中的线粒体功能障碍,包括热量限制和各种膳食化合物在内的策略。肥胖通过破坏线粒体生物发生和动力学对骨骼肌线粒体具有有害作用。热量限制,omega-3脂肪酸,白藜芦醇,和其他膳食化合物增强线粒体功能,并提供有希望的治疗机会。