■这项研究的目的是调查中等强度和高强度运动后与代谢疾病相关的肠道微生物群的变化。共有24名参与者分为三组:非运动组(NEG,n=8,28.6±5.3年,176.0±7.8cm,81.3±14.6kg),中等强度运动组(MIEG,n=8,26.5±3.3年,176.9±5.0cm,75.4±9.5kg),和剧烈强度锻炼小组(VEIG,n=8,30.6±5.9年,174.2±3.5cm,77.8±12.2kg)。
■通过评估身体活动来选择参与者,肠道健康状况,疾病的存在,最近的疾病诊断,和饮食失调。那些报告任何存在疾病或最近疾病诊断的人被排除在本研究之外。在10小时禁食后收集粪便样品用于肠道微生物组分析。MIEG参与者在40-59%的心率储备(HRR)下每周至少训练150分钟,而VEG参与者在≥60%的HRR下每周至少训练90分钟。4周后,所有参与者提供粪便样本进行肠道微生物组分析.数据分析采用Wilcoxon检验,具有统计学意义的≤0.05。
■结果表明,MIEG中普雷沃氏菌的增加,而Veillonella,Dorea_formicitgenerans,Dorea_longicatena表现出下降(p<0.05)。在VIEG中,拟杆菌的数量有所增加,Butyricicimonas,Odoribacter,和Alistipes(p<0.05)。
■这些修饰的微生物群与代谢疾病相关因素有关,包括炎症性肠病,肥胖,结直肠癌,糖尿病,高血压,代谢性肝病,和缺血性心脏病。其他研究对于深入研究运动与微生物组这些变化之间的关系至关重要。
UNASSIGNED: The purpose of this study is to investigate changes in gut microbiota related to metabolic diseases after moderate and high-intensity exercise. A total of 24 participants were divided into three groups: Non-Exercise Group (NEG, n = 8, 28.6 ± 5.3 years, 176.0 ± 7.8 cm, 81.3 ± 14.6 kg), Moderate Intensity Exercise Group (MIEG, n = 8, 26.5 ± 3.3 years, 176.9 ± 5.0 cm, 75.4 ± 9.5 kg), and Vigorous Intensity Exercise Group (VIEG, n = 8, 30.6 ± 5.9 years, 174.2 ± 3.5 cm, 77.8 ± 12.2 kg).
UNASSIGNED: The participants were selected by assessing physical activity, gut health status, presence of diseases, recent disease diagnoses, and dietary disorders. Those who reported any presence disease or recent disease diagnosis were excluded from the current study. Stool samples were collected after a 10-h fast for gut microbiome analysis. MIEG participants trained at 40-59 % heart rate reserve (HRR) for at least 150 min per week, while VIEG participants trained at ≥ 60 % HRR for at least 90 min per week. After 4 weeks, all participants provided stool samples for gut microbiome analysis.Data analysis was conducted using the Wilcoxon test, with statistical significance set at ≤ 0.05.
UNASSIGNED: The results indicated an increase in Prevotella in MIEG, while Veillonella, Dorea_formicigenerans, and Dorea_longicatena exhibited a decrease (p < 0.05). In VIEG, there was an increase in Bacteroides, Butyricimonas, Odoribacter, and Alistipes (p < 0.05).
UNASSIGNED: These modified microbial groups were associated with factors related to metabolic diseases, including inflammatory bowel disease, obesity, colorectal cancer, diabetes, hypertension, metabolic liver diseases, and ischemic heart diseases. Additional research is essential to delve into the relationship between exercise and these alterations in the microbiome.