PDF(Pubmed)
Abstract：
UNASSIGNED: Therapeutic monoclonal antibodies (mAbs) have demonstrated promising outcomes in diverse clinical indications, including but not limited to graft rejection, cancer, and autoimmune diseases lately.Recognizing the crucial need for the scientific community to quickly and easily access dependable information on monoclonal antibodies (mAbs), IMGT®, the international ImMunoGeneTics information system®, provides a unique and invaluable resource: IMGT/mAb-DB, a comprehensive database of therapeutic mAbs, accessible via a user-friendly web interface. However, this approach restricts more sophisticated queries and segregates information from other databases.
UNASSIGNED: To connect IMGT/mAb-DB with the rest of the IMGT databases, we created IMGT/mAb-KG, a knowledge graph for therapeutic monoclonal antibodies connected to IMGT structures and genomics databases. IMGT/mAb-KG is developed using the most effective methodologies and standards of semantic web and acquires data from IMGT/mAb-DB. Concerning interoperability, IMGT/mAb-KG reuses terms from biomedical resources and is connected to related resources.
UNASSIGNED: In February 2024, IMGT/mAb-KG, encompassing a total of 139,629 triplets, provides access to 1,489 mAbs, approximately 500 targets, and over 500 clinical indications. It offers detailed insights into the mechanisms of action of mAbs, their construction, and their various products and associated studies. Linked to other resources such as Thera-SAbDab (Therapeutic Structural Antibody Database), PharmGKB (a comprehensive resource curating knowledge on the impact of genetic variation on drug response), PubMed, and HGNC (HUGO Gene Nomenclature Committee), IMGT/mAb-KG is an essential resource for mAb development. A user-friendly web interface facilitates the exploration and analyse of the content of IMGT/mAb-KG.
UNASSIGNED: To connect IMGT/mAb-DB with the rest of the IMGT databases, we created IMGT/mAb-KG, a knowledge graph for therapeutic monoclonal antibodies connected to IMGT structures and genomics databases. IMGT/mAb-KG is developed using the most effective methodologies and standards of semantic web and acquires data from IMGT/mAb-DB. Concerning interoperability, IMGT/mAb-KG reuses terms from biomedical resources and is connected to related resources.
UNASSIGNED: In February 2024, IMGT/mAb-KG, encompassing a total of 139,629 triplets, provides access to 1,489 mAbs, approximately 500 targets, and over 500 clinical indications. It offers detailed insights into the mechanisms of action of mAbs, their construction, and their various products and associated studies. Linked to other resources such as Thera-SAbDab (Therapeutic Structural Antibody Database), PharmGKB (a comprehensive resource curating knowledge on the impact of genetic variation on drug response), PubMed, and HGNC (HUGO Gene Nomenclature Committee), IMGT/mAb-KG is an essential resource for mAb development. A user-friendly web interface facilitates the exploration and analyse of the content of IMGT/mAb-KG.
摘要：
■治疗性单克隆抗体（mAb）在不同的临床适应症中显示出有希望的结果，包括但不限于移植排斥，癌症,和最近的自身免疫性疾病。认识到科学界迫切需要快速，轻松地获取有关单克隆抗体（mAb）的可靠信息，IMGT®,国际ImMunoGeneTics信息系统®，提供了独特而宝贵的资源：IMGT/mAb-DB，一个全面的治疗性单克隆抗体数据库，可通过用户友好的Web界面访问。然而,这种方法限制了更复杂的查询，并将信息与其他数据库隔离。
■要将IMGT/mAb-DB与其余IMGT数据库连接，我们创建了IMGT/mAb-KG，连接到IMGT结构和基因组学数据库的治疗性单克隆抗体的知识图谱。IMGT/mAb-KG使用最有效的语义网方法和标准开发，并从IMGT/mAb-DB获取数据。关于互操作性，IMGT/mAb-KG重复使用来自生物医学资源的术语，并连接到相关资源。
■2024年2月，IMGT/mAb-KG，包括总共139,629个三胞胎，提供对1,489单克隆抗体的访问，大约500个目标，和500多个临床适应症。它提供了对单克隆抗体作用机制的详细见解，他们的建筑,以及他们的各种产品和相关研究。链接到其他资源，如Thera-SAbDab（治疗性结构抗体数据库），PharmGKB（关于遗传变异对药物反应影响的综合资源管理知识），PubMed,和HGNC（HUGO基因命名委员会），IMGT/mAb-KG是mAb开发的重要资源。用户友好的Web界面有助于探索和分析IMGT/mAb-KG的内容。
■要将IMGT/mAb-DB与其余IMGT数据库连接，我们创建了IMGT/mAb-KG，连接到IMGT结构和基因组学数据库的治疗性单克隆抗体的知识图谱。IMGT/mAb-KG使用最有效的语义网方法和标准开发，并从IMGT/mAb-DB获取数据。关于互操作性，IMGT/mAb-KG重复使用来自生物医学资源的术语，并连接到相关资源。
■2024年2月，IMGT/mAb-KG，包括总共139,629个三胞胎，提供对1,489单克隆抗体的访问，大约500个目标，和500多个临床适应症。它提供了对单克隆抗体作用机制的详细见解，他们的建筑,以及他们的各种产品和相关研究。链接到其他资源，如Thera-SAbDab（治疗性结构抗体数据库），PharmGKB（关于遗传变异对药物反应影响的综合资源管理知识），PubMed,和HGNC（HUGO基因命名委员会），IMGT/mAb-KG是mAb开发的重要资源。用户友好的Web界面有助于探索和分析IMGT/mAb-KG的内容。
