背景:非酒精性脂肪性肝病(NAFLD)是一种在全球范围内普遍存在的肝脏疾病,与重大的健康风险和经济负担相关。由于它与胰岛素抵抗(IR)有关,本研究旨在进行文献计量学分析,直观地呈现关于IR和NAFLD的科学文献.
目标:绘制研究图景,强调重点领域,有影响力的研究,以及NAFLD和IR的未来方向。
方法:本研究对1999年至2022年在SciVerseScopus数据库中索引的IR和NAFLD的文献进行了文献计量分析。搜索策略使用文献和医学主题词中的术语,专注于与IR和NAFLD相关的术语。VOSviewer软件用于可视化研究趋势,合作,和关键主题领域。分析检查了出版物类型,年度研究成果,作出贡献的国家和机构,资助机构,期刊影响因素,引文模式,和高度引用的参考文献。
结果:此分析确定了关于NAFLD的23124份文件,揭示了1999年至2022年间出版物数量的显著增加。搜索检索到715篇关于IR和NAFLD的论文,包括573篇(80.14%)文章和88篇(12.31%)评论。生产率最高的国家是中国(n=134;18.74%),美国(n=122;17.06%),意大利(n=97;13.57%),日本(n=41;5.73%)。领先的机构包括都灵大学,意大利(n=29;4.06%),和纳西亚拉·德尔·里切,意大利(n=19;2.66%)。最高的资助机构是美国国立糖尿病,消化和肾脏疾病研究所(n=48;6.71%),国家自然科学基金(n=37;5.17%)。该领域最活跃的期刊是肝病学(27种出版物),肝病学杂志(17种出版物),和临床内分泌学和代谢杂志(13种出版物)。主要研究热点是“IR和NAFLD的治疗方法”和“炎症和高脂饮食对NAFLD的影响”。
结论:这是第一个研究IR和NAFLD之间关系的文献计量分析。为了应对NAFLD不断升级的全球健康挑战,这项研究强调迫切需要更好地了解这种情况并制定干预策略.政策制定者需要优先考虑和解决日益流行的NAFLD。
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a liver condition that is prevalent worldwide and associated with significant health risks and economic burdens. As it has been linked to insulin resistance (IR), this study aimed to perform a bibliometric analysis and visually represent the scientific literature on IR and NAFLD.
OBJECTIVE: To map the research landscape to underscore critical areas of focus, influential studies, and future directions of NAFLD and IR.
METHODS: This study conducted a bibliometric analysis of the literature on IR and NAFLD indexed in the SciVerse Scopus database from 1999 to 2022. The search strategy used terms from the literature and medical subject headings, focusing on terms related to IR and NAFLD. VOSviewer software was used to visualize research trends, collaborations, and key thematic areas. The analysis examined publication type, annual research output, contributing countries and institutions, funding agencies, journal impact factors, citation patterns, and highly cited references.
RESULTS: This analysis identified 23124 documents on NAFLD, revealing a significant increase in the number of publications between 1999 and 2022. The search retrieved 715 papers on IR and NAFLD, including 573 (80.14%) articles and 88 (12.31%) reviews. The most productive countries were China (n = 134; 18.74%), the United States (n = 122; 17.06%), Italy (n = 97; 13.57%), and Japan (n = 41; 5.73%). The leading institutions included the Università degli Studi di Torino, Italy (n = 29; 4.06%), and the Consiglio Nazionale delle Ricerche, Italy (n = 19; 2.66%). The top funding agencies were the National Institute of Diabetes and Digestive and Kidney Diseases in the United States (n = 48; 6.71%), and the National Natural Science Foundation of China (n = 37; 5.17%). The most active journals in this field were Hepatology (27 publications), the Journal of Hepatology (17 publications), and the Journal of Clinical Endocrinology and Metabolism (13 publications). The main research hotspots were \"therapeutic approaches for IR and NAFLD\" and \"inflammatory and high-fat diet impacts on NAFLD\".
CONCLUSIONS: This is the first bibliometric analysis to examine the relationship between IR and NAFLD. In response to the escalating global health challenge of NAFLD, this research highlights an urgent need for a better understanding of this condition and for the development of intervention strategies. Policymakers need to prioritize and address the increasing prevalence of NAFLD.