Abstract：
OBJECTIVE: This study aims to introduce the coefficient of spatial variance of choroidal thickness to describe the choroidal variation and investigate its associated factors in healthy eyes.
METHODS: This retrospective cross-sectional study included 1031 eyes from 1031 subjects who received a swept-source optical coherence tomography examination. The mean choroidal thickness in the macular 6 × 6 mm region and 900 subregions of 0.2 × 0.2 mm were computed using the embedded algorithm. Before analysis, potential segmentation and magnification errors were corrected. The coefficient of spatial variance was defined as the standard deviation divided by the mean (multiplied by 100%) of the choroidal thicknesses across 900 grids. Potential factors associated with the coefficient of spatial variance were assessed using multiple linear regression.
RESULTS: The mean choroidal thickness of the entire 6 × 6 mm macular region was 204.50 ± 72.88 μm. The mean coefficient of spatial variance was 26.58 ± 8.24%, ranging from 11.00 to 61.58%. Statistical analysis revealed that the means choroidal thickness (β = - 0.08, R2 = 0.42, p < 0.001) and anterior chamber depth (β = - 2.39, R2 = 0.05, p = 0.06) were associated with the coefficient of spatial variance.
CONCLUSIONS: Our study first incorporated the coefficient of spatial variance to represent the spatial variation of the choroidal thickness and observed that the greater thinning of the choroid is correlated with a more pronounced spatial variation.
METHODS: This retrospective cross-sectional study included 1031 eyes from 1031 subjects who received a swept-source optical coherence tomography examination. The mean choroidal thickness in the macular 6 × 6 mm region and 900 subregions of 0.2 × 0.2 mm were computed using the embedded algorithm. Before analysis, potential segmentation and magnification errors were corrected. The coefficient of spatial variance was defined as the standard deviation divided by the mean (multiplied by 100%) of the choroidal thicknesses across 900 grids. Potential factors associated with the coefficient of spatial variance were assessed using multiple linear regression.
RESULTS: The mean choroidal thickness of the entire 6 × 6 mm macular region was 204.50 ± 72.88 μm. The mean coefficient of spatial variance was 26.58 ± 8.24%, ranging from 11.00 to 61.58%. Statistical analysis revealed that the means choroidal thickness (β = - 0.08, R2 = 0.42, p < 0.001) and anterior chamber depth (β = - 2.39, R2 = 0.05, p = 0.06) were associated with the coefficient of spatial variance.
CONCLUSIONS: Our study first incorporated the coefficient of spatial variance to represent the spatial variation of the choroidal thickness and observed that the greater thinning of the choroid is correlated with a more pronounced spatial variation.
摘要：
目的：本研究旨在引入脉络膜厚度的空间变异系数来描述脉络膜的变化，并研究其在健康眼睛中的相关因素。
方法：这项回顾性横断面研究包括来自1031名接受扫频源光学相干断层扫描检查的受试者的1031只眼睛。使用嵌入式算法计算黄斑6×6mm区域和900个0.2×0.2mm子区域的平均脉络膜厚度。在分析之前，校正了潜在的分割和放大误差。空间变化系数定义为900个网格上脉络膜厚度的标准偏差除以平均值(乘以100%)。使用多元线性回归评估与空间方差系数相关的潜在因素。
结果：整个6×6mm黄斑区的平均脉络膜厚度为204.50±72.88μm。空间方差的平均系数为26.58±8.24%，从11.00到61.58%不等。统计分析表明，平均脉络膜厚度（β=-0.08，R2=0.42，p<0.001）和前房深度（β=-2.39，R2=0.05，p=0.06）与空间变异系数相关。
结论：我们的研究首先结合了空间变异系数来表示脉络膜厚度的空间变化，并观察到脉络膜变薄越多，空间变化越明显。
方法：这项回顾性横断面研究包括来自1031名接受扫频源光学相干断层扫描检查的受试者的1031只眼睛。使用嵌入式算法计算黄斑6×6mm区域和900个0.2×0.2mm子区域的平均脉络膜厚度。在分析之前，校正了潜在的分割和放大误差。空间变化系数定义为900个网格上脉络膜厚度的标准偏差除以平均值(乘以100%)。使用多元线性回归评估与空间方差系数相关的潜在因素。
结果：整个6×6mm黄斑区的平均脉络膜厚度为204.50±72.88μm。空间方差的平均系数为26.58±8.24%，从11.00到61.58%不等。统计分析表明，平均脉络膜厚度（β=-0.08，R2=0.42，p<0.001）和前房深度（β=-2.39，R2=0.05，p=0.06）与空间变异系数相关。
结论：我们的研究首先结合了空间变异系数来表示脉络膜厚度的空间变化，并观察到脉络膜变薄越多，空间变化越明显。
