目的:本研究的目的是评估眼,角膜,和圆锥角膜(KC)眼的内部像差参数,圆锥角膜(FFKC),正常的眼睛
方法:在一项前瞻性研究中,110名KC患者的一只眼睛,60名FFKC患者,使用OPD-ScanII对150名健康参与者进行了评估。眼部,角膜,和内部高阶像差通过六阶Zernike多项式分解测量。进行了接收器工作特性分析,以评估像差参数在区分KC和FFKC与正常眼方面的诊断能力。
结果:KC和FFKC患者的所有眼像差测量值均方根均显着高于正常参与者(p<0.05)。KC患者的所有角膜像差测量值均明显高于正常患者(p<0.05)。仅角膜总高阶像差(HOA),垂直和完全昏迷,FFKC患者的高阶散光明显高于正常参与者(p<0.05)。结果还表明,内部像差低阶散光,总三叶形,KC组和正常组的总高阶球差差异有统计学意义(p<0.05)。相比之下,内部总HOA,低阶和高阶散光,总三叶形,FFKC和正常组之间的垂直昏迷显着差异(p<0.05)。眼睛垂直和完全昏迷在区分角膜与正常眼睛方面的能力最高。在区分FFKC与正常眼方面,眼部总畸变和总昏迷具有最高的诊断能力。内部畸变的诊断能力,另一方面,在区分KC和FFKC与正常眼睛方面是中等到较差的。
结论:发现眼像差,尤其是垂直和完全昏迷以及总HOA是区分KC和FFKC与正常患者的合适参数。这两个参数可以用作评估患者屈光手术的区别因素,以避免医源性扩张。
OBJECTIVE: The purpose of this study is to evaluate ocular, corneal, and internal aberration parameters in eyes with keratoconus (KC), forme fruste keratoconus (FFKC), and normal eyes.
METHODS: In a prospective study, one eye of 110 patients with KC, 60 FFKC patients, and 150 healthy participants was evaluated using OPD-Scan II. Ocular, corneal, and internal higher-order aberrations were measured through a sixth-order Zernike polynomial decomposition. Receiver operating characteristic analysis was performed to evaluate the diagnostic ability of the aberration parameters in discriminating KC and FFKC from normal eyes.
RESULTS: The root mean square of the all ocular aberration measurements was significantly higher in the KC and FFKC patients than that of normal participants (p < 0.05). All of the corneal aberration measurements were significantly higher in KC patients than those of normal patients (p < 0.05); however, only corneal total higher-order aberration (HOA), vertical and total coma, and higher-order astigmatism were significantly higher in the FFKC patients than normal participants (p < 0.05). The results also showed that internal aberration lower-order astigmatism, total trefoil, and total higher-order spherical aberration were significantly different between KC and normal groups (p < 0.05). In comparison, internal total HOA, lower and higher-order astigmatism, total trefoil, and vertical coma were significantly different between FFKC and normal groups (p < 0.05). Ocular vertical and total coma had the highest ability in discriminating keratoconic from normal eyes. Ocular total higher aberration and total coma had the highest diagnostic ability in discriminating FFKC from normal eyes. The diagnostic ability of internal aberration, on the other hand, was moderate to poor in discriminating KC and FFKC from normal eyes.
CONCLUSIONS: Ocular aberration especially vertical and total coma and total HOA were found to be suitable parameters to discriminate KC and FFKC from normal patients. These two parameters could be used as discriminating factors in evaluating the patient for refractive surgery in an attempt to avoid iatrogenic ectasia.