Abstract：
OBJECTIVE: To evaluate the retinal vessel density (VD) with optical coherence tomography angiography (OCTA) in asymptomatic patients affected by Waldenström macroglobulinemia (WM) without hyperviscosity syndrome (HVS) and to highlight the presence of microvascular damage in theese clinically asymptomatic WD patients.
METHODS: Prospective study.
METHODS: A total of 43 eyes from 43 WM patients (24 females, 19 males, mean age 55.1 ± 13.6 years) were enrolled from January 2023 to December 2023 in the Eye Clinic of the University of Naples Federico II. Along with WM patients, 40 healthy subjects (HS) (20 females, 20 males, mean age 52.3 ± 15.6 years) with a normal ophthalmic examination and no history of intraocular surgery or retinal pathologic features were included as control group All patients and controls underwent OCTA RESULTS: The two groups were not significantly different for age and sex Visual acuity examination showed no statistically significant difference in BCVA between controls and patients Compared to HS, WD patients showed lower VD values in the SCP in the whole image (47.95 ± 5.17% vs. 52.99 ± 2.52 %; p < 0.001), as well as in the parafovea (53.01 ± 6.69% vs. 55.30 ± 2.61 %; p = 0.002), and fovea (21.38 ± 9.01% vs. 30.31 ± 5.84 %; p < 0.0001). On the other hand, in the DCP VD values were significantly higher in patients compared to controls in the whole image (55.82 ± 8.07% vs. 50.83 ± 5.46 %; p = 0.005), as well as in the parafovea (56.76 ± 6.26% vs. 52.59 ± 5.46 %; p = 0.0001), and fovea (38.75 ± 8.59% vs. 33.43 ± 8.68 %; p < 0.0001).
CONCLUSIONS: The finding that OCTA confirmed the presence of widespread microvascular damage in WD patients clinically silent. Thus, OCTA is a safe rapid imaging technique that could represent a valid biomarker of systemic vascular dysfunction.
METHODS: Prospective study.
METHODS: A total of 43 eyes from 43 WM patients (24 females, 19 males, mean age 55.1 ± 13.6 years) were enrolled from January 2023 to December 2023 in the Eye Clinic of the University of Naples Federico II. Along with WM patients, 40 healthy subjects (HS) (20 females, 20 males, mean age 52.3 ± 15.6 years) with a normal ophthalmic examination and no history of intraocular surgery or retinal pathologic features were included as control group All patients and controls underwent OCTA RESULTS: The two groups were not significantly different for age and sex Visual acuity examination showed no statistically significant difference in BCVA between controls and patients Compared to HS, WD patients showed lower VD values in the SCP in the whole image (47.95 ± 5.17% vs. 52.99 ± 2.52 %; p < 0.001), as well as in the parafovea (53.01 ± 6.69% vs. 55.30 ± 2.61 %; p = 0.002), and fovea (21.38 ± 9.01% vs. 30.31 ± 5.84 %; p < 0.0001). On the other hand, in the DCP VD values were significantly higher in patients compared to controls in the whole image (55.82 ± 8.07% vs. 50.83 ± 5.46 %; p = 0.005), as well as in the parafovea (56.76 ± 6.26% vs. 52.59 ± 5.46 %; p = 0.0001), and fovea (38.75 ± 8.59% vs. 33.43 ± 8.68 %; p < 0.0001).
CONCLUSIONS: The finding that OCTA confirmed the presence of widespread microvascular damage in WD patients clinically silent. Thus, OCTA is a safe rapid imaging technique that could represent a valid biomarker of systemic vascular dysfunction.
摘要：
目的：通过光学相干断层扫描血管造影（OCTA）评估无症状的无症状的Waldenström巨球蛋白血症（WM）患者的视网膜血管密度（VD），并强调无症状的WD患者的微血管损伤。
方法：前瞻性研究。
方法：从43例WM患者（24例女性，19名男性，从2023年1月至2023年12月，平均年龄55.1±13.6岁）在那不勒斯费德里科大学眼科诊所注册。.随着WM患者，40名健康受试者（HS）（20名女性，20名男性,平均年龄52.3±15.6岁），眼科检查正常，无眼内手术史或视网膜病理特征，作为对照组。所有患者和对照组均接受了OCTA检查。WD患者在整个图像中显示SCP的VD值较低（47.95±5.17％vs.52.99±2.52%；p<0.001)，以及在Parafovea（53.01±6.69％vs.55.30±2.61%；p=0.002），和中央凹(21.38±9.01%vs.30.31±5.84%；p<0.0001）。另一方面,在整个图像中，患者的DCPVD值明显高于对照组（55.82±8.07％vs.50.83±5.46%；p=0.005)，以及在Parafovea（56.76±6.26％vs.52.59±5.46%；p=0.0001），和中央凹(38.75±8.59%vs.33.43±8.68%；p<0.0001）。
结论：OCTA的发现证实了临床上无症状的WD患者存在广泛的微血管损伤。因此，OCTA是一种安全的快速成像技术，可以代表全身血管功能障碍的有效生物标志物。
方法：前瞻性研究。
方法：从43例WM患者（24例女性，19名男性，从2023年1月至2023年12月，平均年龄55.1±13.6岁）在那不勒斯费德里科大学眼科诊所注册。.随着WM患者，40名健康受试者（HS）（20名女性，20名男性,平均年龄52.3±15.6岁），眼科检查正常，无眼内手术史或视网膜病理特征，作为对照组。所有患者和对照组均接受了OCTA检查。WD患者在整个图像中显示SCP的VD值较低（47.95±5.17％vs.52.99±2.52%；p<0.001)，以及在Parafovea（53.01±6.69％vs.55.30±2.61%；p=0.002），和中央凹(21.38±9.01%vs.30.31±5.84%；p<0.0001）。另一方面,在整个图像中，患者的DCPVD值明显高于对照组（55.82±8.07％vs.50.83±5.46%；p=0.005)，以及在Parafovea（56.76±6.26％vs.52.59±5.46%；p=0.0001），和中央凹(38.75±8.59%vs.33.43±8.68%；p<0.0001）。
结论：OCTA的发现证实了临床上无症状的WD患者存在广泛的微血管损伤。因此，OCTA是一种安全的快速成像技术，可以代表全身血管功能障碍的有效生物标志物。
