PDF(Pubmed)
Abstract：
UNASSIGNED: To evaluate the association between bedtime and infertility and to identify the optimal bedtime for women of reproductive age.
UNASSIGNED: We conducted a cross-sectional study using data from 3,903 female participants in the National Health and Nutrition Examination Survey (NHANES) from 2015 to 2020. The effect of bedtime on female infertility was assessed using the binary logistic regression in different models, including crude model and adjusted models. To identify the non-linear correlation between bedtime and infertility, generalized additive models (GAM) were utilized. Subgroup analyses were conducted by age, body mass index (BMI), waist circumference, physical activity total time, marital status, smoking status, drinking status and sleep duration.
UNASSIGNED: After adjusting for potential confounders (age, race, sleep duration, waist circumference, marital status, education, BMI, smoking status, drinking status and physical activity total time), a non-linear relationship was observed between bedtime and infertility, with the inflection point at 22:45. To the left side of the inflection point, no significant association was detected. However, to the right of it, bedtime was positively related to the infertility (OR: 1.22; 95% CI: 1.06 to 1.39; P = 0.0049). Subgroup analyses showed that late sleepers with higher BMI were more prone to infertility than those with a lower BMI (BMI: 25-30 kg/m2: OR: 1.26; 95% CI: 1.06 to 1.51; P = 0.0136; BMI ≥ 30 kg/m²: OR: 1.21, 95% CI: 1.09 to 1.34; P = 0.0014).
UNASSIGNED: Bedtime was non-linearly associated with infertility, which may provide guidance for sleep behavior in women of childbearing age.
UNASSIGNED: We conducted a cross-sectional study using data from 3,903 female participants in the National Health and Nutrition Examination Survey (NHANES) from 2015 to 2020. The effect of bedtime on female infertility was assessed using the binary logistic regression in different models, including crude model and adjusted models. To identify the non-linear correlation between bedtime and infertility, generalized additive models (GAM) were utilized. Subgroup analyses were conducted by age, body mass index (BMI), waist circumference, physical activity total time, marital status, smoking status, drinking status and sleep duration.
UNASSIGNED: After adjusting for potential confounders (age, race, sleep duration, waist circumference, marital status, education, BMI, smoking status, drinking status and physical activity total time), a non-linear relationship was observed between bedtime and infertility, with the inflection point at 22:45. To the left side of the inflection point, no significant association was detected. However, to the right of it, bedtime was positively related to the infertility (OR: 1.22; 95% CI: 1.06 to 1.39; P = 0.0049). Subgroup analyses showed that late sleepers with higher BMI were more prone to infertility than those with a lower BMI (BMI: 25-30 kg/m2: OR: 1.26; 95% CI: 1.06 to 1.51; P = 0.0136; BMI ≥ 30 kg/m²: OR: 1.21, 95% CI: 1.09 to 1.34; P = 0.0014).
UNASSIGNED: Bedtime was non-linearly associated with infertility, which may provide guidance for sleep behavior in women of childbearing age.
摘要：
■评估就寝时间与不孕症之间的关系，并确定育龄妇女的最佳就寝时间。
■我们使用2015年至2020年国家健康与营养检查调查（NHANES）的3,903名女性参与者的数据进行了横断面研究。睡前对女性不孕症的影响采用二元logistic回归模型进行评估，包括粗模型和调整后的模型。为了确定就寝时间与不孕症之间的非线性相关性，利用广义加法模型(GAM)。亚组分析按年龄进行，体重指数（BMI），腰围,体力活动总时间,婚姻状况,吸烟状况,饮酒状态和睡眠时间。
■在调整了潜在的混杂因素(年龄，种族,睡眠持续时间,腰围,婚姻状况,教育,BMI,吸烟状况,饮酒状况和身体活动总时间)，观察到就寝时间和不孕症之间存在非线性关系，拐点在22:45。在拐点的左侧，未检测到显著关联.然而,在它的右边，就寝时间与不孕呈正相关(OR:1.22;95%CI:1.06~1.39;P=0.0049)。亚组分析表明，BMI较高的晚睡者比BMI较低的晚睡者更容易不孕（BMI：25-30kg/m2：OR：1.26；95％CI：1.06至1.51；P=0.0136；BMI≥30kg/m²：OR：1.21，95％CI：1.09至1.34；P=0.0014）。
■就寝时间与不孕症呈非线性相关，可以为育龄妇女的睡眠行为提供指导。
■我们使用2015年至2020年国家健康与营养检查调查（NHANES）的3,903名女性参与者的数据进行了横断面研究。睡前对女性不孕症的影响采用二元logistic回归模型进行评估，包括粗模型和调整后的模型。为了确定就寝时间与不孕症之间的非线性相关性，利用广义加法模型(GAM)。亚组分析按年龄进行，体重指数（BMI），腰围,体力活动总时间,婚姻状况,吸烟状况,饮酒状态和睡眠时间。
■在调整了潜在的混杂因素(年龄，种族,睡眠持续时间,腰围,婚姻状况,教育,BMI,吸烟状况,饮酒状况和身体活动总时间)，观察到就寝时间和不孕症之间存在非线性关系，拐点在22:45。在拐点的左侧，未检测到显著关联.然而,在它的右边，就寝时间与不孕呈正相关(OR:1.22;95%CI:1.06~1.39;P=0.0049)。亚组分析表明，BMI较高的晚睡者比BMI较低的晚睡者更容易不孕（BMI：25-30kg/m2：OR：1.26；95％CI：1.06至1.51；P=0.0136；BMI≥30kg/m²：OR：1.21，95％CI：1.09至1.34；P=0.0014）。
■就寝时间与不孕症呈非线性相关，可以为育龄妇女的睡眠行为提供指导。
