Abstract：
Biliary tract neoplasms, which originate from the intrahepatic or extrahepatic biliary epithelium, are relatively rare but diagnostically challenging types of tumours, and their morbidity and mortality have increased in recent years. Due to ineffective early diagnostic methods, once detected, patients are in an advanced stage with a poor prognosis and few treatment options. With the development of omics technologies, the associations between microorganisms, bile acid and salts, noncoding RNAs and biliary tract malignancies have been gradually revealed, providing new methods for the discovery of diagnostic biomarkers. Here, we review the research advances in microbiomics, transcriptomics, metabolomics, and proteomics in the discovery of diagnostic biomarkers for biliary tract malignancies.
摘要：
胆道肿瘤，起源于肝内或肝外胆管上皮，是相对罕见但具有诊断挑战性的肿瘤类型，近年来，他们的发病率和死亡率都在增加。由于早期诊断方法无效，一旦检测到,患者处于晚期，预后不良，治疗选择很少。随着组学技术的发展,微生物之间的联系，胆汁酸和盐，非编码RNA和胆道恶性肿瘤已经逐渐被揭示，为诊断生物标志物的发现提供了新的方法。这里,我们回顾了微生物生物学的研究进展，转录组学，代谢组学，和蛋白质组学在胆道恶性肿瘤诊断生物标志物的发现中。
