PDF(Pubmed)
Abstract：
BACKGROUND: Motoric cognitive risk (MCR) syndrome refers to a condition where both slow gait and memory complaints coexist, which heightens their vulnerability to developing dementia. Considering that the risk factors of MCR are elucidated from cross-sectional studies and also likely vary based on socioeconomic status, we conducted a community-based longitudinal study to determine the predictors of MCR among older adults in Malaysia.
METHODS: Out of 1,249 older participants (aged 60 years and above) without MCR at baseline (Wave II of LRGS-TUA cohort study), 719 were successfully followed up after 3.5 years to identify predictors of subsequent MCR development. A comprehensive interview-based questionnaire was administered for sociodemographic information, cognitive function, psychosocial, functional status, and dietary intake. Anthropometric measurements, body composition, and physical performance were assessed. Univariate analyses were performed for each variable, followed by a hierarchical logistic regression analysis to identify the predictors of MCR that accounted for confounding effects between the studied factors.
RESULTS: The incidence rate of MCR was 4.0 per 100 person-years. Smoking (Adjusted Odd Ratio (Adj OR) = 1.782; 95% Confidence Interval (CI):1.050-3.024), hypertension (Adj OR = 1.725; 95% CI:1.094-2.721), decreased verbal memory as assessed by the lower Rey Auditory Verbal Learning Test (RAVLT) (Adj OR = 1.891; 95% CI:1.103-3.243), and decreased functional status measured using instrumental activity of daily living (IADL) (Adj OR = 4.710; 95% CI:1.319-16.823), were predictors for MCR incidence.
CONCLUSIONS: Our study results provide an initial reference for future studies to formulate effective preventive management and intervention strategies to reduce the growing burden of adverse health outcomes, particularly among Asian older adults.
METHODS: Out of 1,249 older participants (aged 60 years and above) without MCR at baseline (Wave II of LRGS-TUA cohort study), 719 were successfully followed up after 3.5 years to identify predictors of subsequent MCR development. A comprehensive interview-based questionnaire was administered for sociodemographic information, cognitive function, psychosocial, functional status, and dietary intake. Anthropometric measurements, body composition, and physical performance were assessed. Univariate analyses were performed for each variable, followed by a hierarchical logistic regression analysis to identify the predictors of MCR that accounted for confounding effects between the studied factors.
RESULTS: The incidence rate of MCR was 4.0 per 100 person-years. Smoking (Adjusted Odd Ratio (Adj OR) = 1.782; 95% Confidence Interval (CI):1.050-3.024), hypertension (Adj OR = 1.725; 95% CI:1.094-2.721), decreased verbal memory as assessed by the lower Rey Auditory Verbal Learning Test (RAVLT) (Adj OR = 1.891; 95% CI:1.103-3.243), and decreased functional status measured using instrumental activity of daily living (IADL) (Adj OR = 4.710; 95% CI:1.319-16.823), were predictors for MCR incidence.
CONCLUSIONS: Our study results provide an initial reference for future studies to formulate effective preventive management and intervention strategies to reduce the growing burden of adverse health outcomes, particularly among Asian older adults.
摘要：
背景：运动认知风险（MCR）综合征是指步态缓慢和记忆不适并存的情况，这增加了他们发展为痴呆症的脆弱性。考虑到MCR的风险因素是从横断面研究中阐明的，并且也可能根据社会经济地位而有所不同，我们进行了一项基于社区的纵向研究,以确定马来西亚老年人MCR的预测因子.
方法：在基线时没有MCR的1,249名老年参与者（60岁及以上）中（LRGS-TUA队列研究的II波），719人在3.5年后成功随访，以确定随后MCR发展的预测因素。对社会人口统计信息进行了全面的基于访谈的问卷调查，认知功能,社会心理,功能状态，和饮食摄入。人体测量,身体成分,和物理性能进行了评估。对每个变量进行单变量分析，然后进行分层逻辑回归分析,以确定MCR的预测因子,这些预测因子解释了所研究因子之间的混杂效应.
结果：MCR的发生率为4.0/100人年。吸烟（调整后奇数比（调整OR）=1.782；95%置信区间（CI）：1.050-3.024），高血压（调整OR=1.725；95%CI：1.094-2.721），通过较低的Rey听觉言语学习测验（RAVLT）评估的言语记忆力下降（调整OR=1.891；95％CI：1.103-3.243），使用仪器日常生活活动（IADL）测量的功能状态降低（调整OR=4.710；95％CI：1.319-16.823），是MCR发生率的预测因子。
结论：我们的研究结果为未来的研究提供了初步参考，以制定有效的预防管理和干预策略，以减轻日益增加的不良健康结局负担，尤其是亚洲老年人。
方法：在基线时没有MCR的1,249名老年参与者（60岁及以上）中（LRGS-TUA队列研究的II波），719人在3.5年后成功随访，以确定随后MCR发展的预测因素。对社会人口统计信息进行了全面的基于访谈的问卷调查，认知功能,社会心理,功能状态，和饮食摄入。人体测量,身体成分,和物理性能进行了评估。对每个变量进行单变量分析，然后进行分层逻辑回归分析,以确定MCR的预测因子,这些预测因子解释了所研究因子之间的混杂效应.
结果：MCR的发生率为4.0/100人年。吸烟（调整后奇数比（调整OR）=1.782；95%置信区间（CI）：1.050-3.024），高血压（调整OR=1.725；95%CI：1.094-2.721），通过较低的Rey听觉言语学习测验（RAVLT）评估的言语记忆力下降（调整OR=1.891；95％CI：1.103-3.243），使用仪器日常生活活动（IADL）测量的功能状态降低（调整OR=4.710；95％CI：1.319-16.823），是MCR发生率的预测因子。
结论：我们的研究结果为未来的研究提供了初步参考，以制定有效的预防管理和干预策略，以减轻日益增加的不良健康结局负担，尤其是亚洲老年人。
