Older adults

老年人
  • 文章类型: Journal Article
    背景:接受家庭护理的老年人比没有接受家庭护理的社区老年人有更高的去急诊科(ED)的风险。这可能是由于家庭护理接受者的合并症发生率较高和功能自主性降低所致。由于人们因其不同的合并症和自主性而接受不同类型的家庭护理,区分家庭护理的形式可能有助于识别具有不同ED就诊风险的亚人群,并有助于制定有针对性的干预措施.这项研究旨在比较接受不同形式的家庭护理的老年人和在一年内没有接受家庭护理的老年人访问ED的风险。
    方法:使用2019年收集的65岁以上荷兰人口(N=3,314,440)的索赔数据进行了回顾性队列研究。参与者分类如下:没有声称的家庭护理(NO),家庭帮助(HH),个人护理(PC)HH+PC,和家庭护理(NHH)。主要结果是访问ED的人数。次要结果是家庭护理发生变化的人数,被制度化的人,或者谁死了。采用探索性逻辑回归。
    结果:NO组中有2,758,093名成年人,HH组中的131,260,PC组中的154,462,HH+PC组中的96,526,和34,612在NHH基团中。家庭护理组比NO组观察到更多的ED就诊,对于PC组,这种风险增加到两倍以上。更密集的家庭护理形式发生了重大变化,制度化,或所有群体中的死亡。
    结论:区分老年人接受的家庭护理形式可识别出与未接受家庭护理的社区居住老年人相比,ED就诊风险不同的亚人群。家庭护理过渡频繁,主要涉及更多的重症监护或死亡。尽管未接受家庭护理的老年人发生ED的风险较低,他们对ED访问的绝对量贡献最大。
    BACKGROUND: Older adults receiving home care have a higher risk of visiting the emergency department (ED) than community-dwelling older adults not receiving home care. This may result from a higher incidence of comorbidities and reduced functional autonomy in home care recipients. Since people receive different types of home care because of their different comorbidities and autonomy profiles, it is possible that distinguishing between the form of home care can help identify subpopulations with different risks for ED visits and help develop targeted interventions. This study aimed to compare the risk of visiting the ED in older adults receiving different forms of home care with those living at home without receiving home care in a national cohort in one year.
    METHODS: A retrospective cohort study using claims data collected in 2019 on the Dutch population aged ≥ 65 years (N = 3,314,440) was conducted. Participants were classified as follows: no claimed home care (NO), household help (HH), personal care (PC), HH + PC, and nursing home care at home (NHH). The primary outcome was the number of individuals that visited the ED. Secondary outcomes were the number of individuals whose home care changed, who were institutionalized, or who died. Exploratory logistic regression was applied.
    RESULTS: There were 2,758,093 adults in the NO group, 131,260 in the HH group, 154,462 in the PC group, 96,526 in the HH + PC group, and 34,612 in the NHH group. More ED visits were observed in the home care groups than in the NO group, and this risk increased to more than two-fold for the PC groups. There was a significant change to a more intensive form of home care, institutionalization, or death in all groups.
    CONCLUSIONS: Distinguishing between the form of home care older adults receive identifies subpopulations with different risks for ED visits compared with community-dwelling older adults not receiving home care on a population level. Home care transitions are frequent and mostly involve more intensive care or death. Although older adults not receiving home care have a lower risk of ED visits, they contribute most to the absolute volume of ED visits.
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  • 文章类型: Journal Article
    确定影响患有常见心理健康问题(CMHP)的老年人心理治疗结果的因素对于支持更健康和更长寿具有重要意义。本研究的目的是综合老年人(65岁以上)心理治疗结果预测因素的证据。PubMed,Scopus,搜索了WebofScience和PsycINFO,并确定和筛选了3929篇文章,42项研究(N=7978,M年龄=68.9,SD年龄=2.85)包括:抑郁:k=21,焦虑:k=11,恐慌症:k=3,混合焦虑和抑郁:k=3,PTSD:k=2,各种CMHP:k=2,CBT是最常见的治疗方法(71%)。该综述确定了至少一项研究中报告的28个因素是治疗结果的重要预测因素,跨不同领域:社会心理(n=9),临床(n=6),治疗相关(n=6),社会人口学(n=4),神经生物学(n=3)。完成家庭作业是积极治疗结果的最一致预测指标。基线症状严重程度是最常研究的重要预测因素,在所有情况下,较高的基线症状严重程度在很大程度上与较差的治疗结果相关。性别对治疗结果无显著影响,收入和身体合并症。对于绝大多数因素,证据是混合的或不确定的。需要进一步的研究来确定影响心理治疗结果的因素,这对个性化治疗方法的发展至关重要。
    Identifying factors that impact psychological treatment outcomes in older people with common mental health problems (CMHP) has important implications for supporting healthier and longer lives. The aim of the present study was to synthesise the evidence on predictors of psychological treatment outcomes in older people (aged 65+). PubMed, Scopus, Web of Science and PsycINFO were searched and 3929 articles were identified and screened, with 42 studies (N = 7978, M age = 68.9, SD age = 2.85) included: depression: k = 21, anxiety: k = 11, panic disorder: k = 3, mixed anxiety & depression: k = 3, PTSD: k = 2, various CMHP: k = 2, with CBT being the most common treatment (71%). The review identified 28 factors reported as significant predictors of treatment outcome in at least one study, across different domains: psychosocial (n = 9), clinical (n = 6), treatment-related (n = 6), socio-demographic (n = 4), neurobiological (n = 3). Homework completion was the most consistent predictor of positive treatment outcome. Baseline symptom severity was the most frequently studied significant predictor and across all conditions, with higher baseline symptom severity largely linked to worse treatment outcomes. No significant effects on treatment outcome were reported for gender, income and physical comorbidities. For a large majority of factors evidence was mixed or inconclusive. Further studies are required to identify factors affecting psychological treatment outcomes, which will be important for the development of personalised treatment approaches.
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  • 文章类型: Journal Article
    背景:车辆行驶取决于电动机的集成,视觉,和认知技能,以适当地应对交通中发生的不同情况。
    目的:分析驾驶模拟器中制动时间的性能预测模型,使用一系列按性别划分的测试。
    方法:选取100名男性驾驶员,平均年龄72.6±5.7岁。社会人口统计学变量,驾驶模拟器中的制动时间,和电机,视觉,和认知技能进行了评估。
    结果:比较性别,男性年龄大于女性(p=0.002),驾驶时间较长(p=0.001).男性的握力更强(p≤0.001)。在线性回归分析中,该模型解释了68%的男性制动时间和50.8%的女性制动时间。在逐步多元线性回归分析中,模型中剩下的变量是右足底屈肌的强度,这解释了女性和男性13%的刹车时间,认知变量解释了38.9%。
    结论:社会人口统计,电机,视觉,和认知变量,解释了老年女性和男性制动时间变化的很大一部分,推动这一表现的具体变量在两性之间是不同的。对于年长的女性来说,肌肉力量等因素成为制动能力的关键决定因素,强调身体健康在保持驾驶技能方面的重要性。另一方面,认知状况成为老年男性制动性能的主要预测指标,强调精神敏锐度和决策过程在安全驾驶中的作用。
    BACKGROUND: Vehicle driving depends on the integration of motor, visual, and cognitive skills to respond appropriately to different situations that occur in traffic.
    OBJECTIVE: To analyze a model of performance predictor for braking time in the driving simulator, using a battery of tests divided by gender.
    METHODS: Selected were 100 male drivers with a mean age of 72.6 ± 5.7 years. Sociodemographic variables, braking time in the driving simulator, and motor, visual, and cognitive skills were evaluated.
    RESULTS: Comparing genders, men were older than women (p = 0.002) and had longer driving times (p = 0.001). Men had more strength in hand grip (p ≤ 0.001). In the linear regression analysis, the model explained 68 % of the braking time in men and 50.8 % in women. In the stepwise multiple linear regression analysis, the variable that remained in the model was the strength of the right plantar flexors, which explained 13 % of the braking time in women and men, and the cognitive variables explained 38.9 %.
    CONCLUSIONS: Sociodemographic, motor, visual, and cognitive variables, explained a substantial portion of the variability in braking time for both older women and men, the specific variables driving this performance differed between the sexes. For older women, factors such as muscle strength emerged as critical determinants of braking ability, highlighting the importance of physical health in maintaining driving skills. On the other hand, cognitive conditions emerged as the primary predictor of braking performance in older men, underscoring the role of mental acuity and decision-making processes in safe driving.
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  • 文章类型: Journal Article
    背景:关于城市和农村地区患有多种慢性疾病(MCC)的老年人之间抑郁症状差异的证据有限。
    方法:抑郁症状的测量(流行病学研究中心抑郁量表-10)和人口统计学因素(年龄,性别,和城乡分布)被使用。
    结果:本研究共纳入4021名患有MCC的老年人。在两个网络的全球实力上都观察到了显著差异(Urban:3.989vs.农村:3.703,S=0.286,p=0.003),城乡居民之间的网络结构(M=0.139,p=0.002)。
    结论:该研究强调需要针对特定地区的方法来了解和解决抑郁症,并有可能提高对城市和农村地区患有MCC的老年人的心理健康状况的了解。
    BACKGROUND: Evidence on the differences in depressive symptoms among older adults with multiple chronic conditions (MCCs) in urban and rural areas is limited.
    METHODS: Measures of depressive symptoms (Center for Epidemiologic Studies Depression Scale-10) and demographic factors (age, gender, and urban-rural distribution) were used.
    RESULTS: A total of 4021 older adults with MCCs were included in this study. Significant differences were observed in both network global strength (Urban: 3.989 vs. Rural: 3.703, S = 0.286, p = 0.003) and network structure (M = 0.139, p = 0.002) between urban and rural residents.
    CONCLUSIONS: The study highlights the need for region-specific approaches to understanding and addressing depression and holds the potential to enhance understanding of the psychological health status of older adults with MCCs in urban and rural settings.
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  • 文章类型: Journal Article
    运动评估已成为检测晚年认知障碍的补充证据。临床医生缺乏廉价,准确,和便携式工具用于此目的。为了填补这个空白,当前的研究从Mizzou点护理评估系统的多模态传感器平台试点措施。我们检查了这些运动功能测量区分神经认知状态的能力,并评估了它们与认知表现的关联。数据来自42名老年人,包括16例轻度认知障碍(MCI)。参与者执行双重任务步态,配对步行与串行减法七分,还有aa神经心理学测试电池。T检验显示,与健康的老年人相比,MCI患者的步幅时间较慢(d=.55)和步幅较短(d=.98)。分层回归的结果表明,跨步时间和跨步长度可以预测多个领域的认知表现,在控制认知状态和人口统计学后。认知状态调节了这种全球认知和注意力的关系,其中步态测量与认知正常组的这些结果显着相关,但不是MCI集团.来自当前研究的证据提供了初步支持,即MPASS测量显示出与认知表现的预期关联,并且可以区分有和没有认知障碍的人。
    Motor assessment has emerged as complementary evidence for the detection of late life cognitive disorders. Clinicians lack inexpensive, accurate, and portable tools for this purpose. To fill this void, the current study piloted measures from the Mizzou Point-of-care Assessment System a multimodal sensor platform. We examined the ability of these motor function measures to distinguish neurocognitive status and assessed their associations with cognitive performance. Data came from 42 older adults, including 16 with mild cognitive impairment (MCI). Participants performed dual task gait, pairing walking with serial subtraction by sevens, along with aa neuropsychological test battery. T-tests revealed that individuals with MCI demonstrated slower stride times (d = .55) and shorter stride lengths (d = .98) compared to healthy older adults. Results from hierarchical regression showed that stride time and stride length predicted cognitive performance across several domains, after controlling for cognitive status and demographics. Cognitive status moderated this relationship for global cognition and attention, wherein gait measures were significantly related to these outcomes for the cognitively normal group, but not the MCI group. Evidence from the current study provided preliminary support that MPASS measures demonstrate expected associations with cognitive performance and can distinguish amongst those with and without cognitive impairment.
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  • 文章类型: Journal Article
    运动对健康有益,但可引起氧化应激和炎症,特别是在高强度形式,如高强度间歇运动(IIIE)。Exragaming已经成为一种有效的,适合所有年龄段的健身工具,尤其是老年人。酶补充剂可以通过改善乳酸代谢和减少氧化应激来增强运动表现。
    这项研究调查了水果和蔬菜酶补充剂在调节HIIE后老年人的疲劳和增强有氧能力方面的功效。
    该研究招募了16名年龄较大的成年女性参与者,并根据他们的预测乳酸水平将他们分为2个不同的组(酶和安慰剂)。这种划分使用成对分组来保证组之间的可比性,确保结果的完整性。他们使用任天堂SwitchRingFitAdventure从事HIIE,进行8组20秒的最大努力运动,穿插30秒的休息,总共370秒的锻炼。评估的关键指标包括血乳酸水平,心率,感知努力的评级,和训练冲动。酶组的参与者在14天内每天两次以30mL的剂量给予水果和蔬菜酶补充剂。
    与安慰剂组相比,酶组血乳酸水平明显降低,特别是在第四次(平均4.29,SD0.67与平均6.34,SD1.17mmol/L;P=.001)和第八次(平均5.84,SD0.63与平均8.20,SD1.15mmol/L;P<.001)运动之后。这种趋势在运动后5分钟(平均6.85,SD0.82与平均8.60,SD1.13mmol/L;P=.003)和10分钟(平均5.91,SD1.16与平均8.21,SD1.27mmol/L;P=.002)持续。尽管两组在运动过程中都超过了其估计最大心率的85%,补充酶没有明显影响感知的强度或努力。
    该研究表明,水果和蔬菜酶补充剂可以通过运动游戏显着降低HIIE后老年人的血乳酸水平。这表明这些酶在调节高强度运动期间和之后的乳酸产生或清除中的潜在作用。这些发现对制定有针对性的干预措施以增强老年人的运动耐量和康复具有重要意义。
    UNASSIGNED: Exercise offers substantial health benefits but can induce oxidative stress and inflammation, especially in high-intensity formats such as high-intensity interval exercise (HIIE). Exergaming has become an effective, enjoyable fitness tool for all ages, particularly older adults. Enzyme supplements may enhance exercise performance by improving lactate metabolism and reducing oxidative stress.
    UNASSIGNED: This study investigates the efficacy of fruit and vegetable enzyme supplementation in modulating fatigue and enhancing aerobic capacity in older adults following HIIE through exergaming.
    UNASSIGNED: The study recruited 16 older adult female participants and allocated them into 2 distinct groups (enzyme and placebo) based on their pretest lactate levels. This division used pairwise grouping to guarantee comparability between the groups, ensuring the integrity of the results. They engaged in HIIE using Nintendo Switch Ring Fit Adventure, performing 8 sets of 20 seconds of maximum effort exercise interspersed with 30 seconds of rest, totaling 370 seconds of exercise. Key metrics assessed included blood lactate levels, heart rate, rating of perceived exertion, and training impulse. Participants in the enzyme group were administered a fruit and vegetable enzyme supplement at a dosage of 30 mL twice daily over a period of 14 days.
    UNASSIGNED: The enzyme group showed significantly lower blood lactate levels compared to the placebo group, notably after the fourth (mean 4.29, SD 0.67 vs mean 6.34, SD 1.17 mmol/L; P=.001) and eighth (mean 5.84, SD 0.63 vs mean 8.20, SD 1.15 mmol/L; P<.001) exercise sessions. This trend continued at 5 minutes (mean 6.85, SD 0.82 vs mean 8.60, SD 1.13 mmol/L; P=.003) and 10 minutes (mean 5.91, SD 1.16 vs mean 8.21, SD 1.27 mmol/L; P=.002) after exercise. Although both groups exceeded 85% of their estimated maximum heart rate during the exercise, enzyme supplementation did not markedly affect the perceived intensity or effort.
    UNASSIGNED: The study indicates that fruit and vegetable enzyme supplementation can significantly reduce blood lactate levels in older adults following HIIE through exergaming. This suggests a potential role for these enzymes in modulating lactate production or clearance during and after high-intensity exercise. These findings have implications for developing targeted interventions to enhance exercise tolerance and recovery in older adults.
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  • 文章类型: Journal Article
    这项研究调查了社会活动对认知功能和精神病理症状的影响。
    55岁或以上的参与者通过社区注册。初步措施评估了人口数据,神经心理功能,精神病理学状态,和幸福。使用改进的12项工具评估社会活动,以3-4个活动为截止点。6-9个月后的随访包括迷你精神状态检查(MMSE),贝克抑郁量表-II(BDI-II),贝克焦虑量表(BAI),健康评估问卷(HAQ)和患者健康问卷-15(PHQ-15)测量。使用多元线性回归建立了精神病和认知状态的预测模型,根据基线条件进行调整。
    最初,516名老年人登记,403正在进行随访。随访期间,低参与组报告MMSE得分较低,更高的BAI分数,增加PHQ-15的风险。发现社交活动数量与PHQ-15结果之间呈负相关。参与社交俱乐部与较高的MMSE分数呈正相关,而与成年子女(ren)的定期互动与BAI评分降低有关。
    社会活动的数量与较低的躯体困扰有关。社交俱乐部参与对认知有积极影响,与成年子女(ren)的定期互动减轻了老年人的焦虑。
    足够类型的社交活动,参加社交俱乐部,以及与儿童的充分互动,防止精神病理学。
    UNASSIGNED: This study investigated the impact of social activities on cognitive functioning and psychopathological symptoms.
    UNASSIGNED: Participants aged 55 or older were enrolled through communities. Initial measures assessed demographic data, neuropsychological functioning, psychopathological state, and happiness. Social activities were evaluated using a modified 12-item tool, with 3-4 activities as the cutoff. Follow-up after 6-9 months included Mini-Mental State Examination (MMSE), Beck Depression Inventory - II (BDI-II), Beck Anxiety Inventory (BAI), Health Assessment Questionnaire (HAQ), and Patient Health Questionnaire-15 (PHQ-15) measurements. Predictive models for psychiatric and cognitive statuses were built using multiple linear regression, adjusting for baseline conditions.
    UNASSIGNED: Initially, 516 older individuals enrolled, with 403 undergoing follow-up. During follow-up, the low participation group reported lower MMSE scores, higher BAI scores, and increased PHQ-15 risk. Negative correlations between social activity numbers and PHQ-15 results were found. Engagement in social clubs correlated positively with higher MMSE scores, while regular interactions with one\'s adult child(ren) were linked to decreased BAI scores.
    UNASSIGNED: The quantity of social activities was associated with lower somatic distress. Social club engagement positively influenced cognition, and regular interactions with one\'s adult child(ren) mitigated anxiety among older individuals.
    UNASSIGNED: Enough types of social activities, participating in social clubs, and adequate interactions with children protected against psychopathologies.
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  • 文章类型: Journal Article
    关于生活在阿拉巴马州农村地区的非裔美国人(AA)老年妇女的心血管疾病(CVD)危险因素知识和实际危险行为的信息有限。进行了一项针对CVD预防行为的需求评估的试点研究,以收集农村AA妇女的此类数据。本文报告了本试点研究的需求评估的定量部分。我们使用便利抽样招募了参与者(N=30)。数据收集措施包括:i)美国心脏协会的心血管疾病相关知识问卷,ii)五次坐立测试以测量动态平衡和iii)六分钟步行测试(6MWT)以评估运动耐力iv)标准体重秤以测量体重和v)标准测量秤以测量身高。使用描述性和推断性统计来分析数据。大多数(76%)的参与者患有高血压(70%),糖尿病(60%)余额差(70%),低运动耐力(100%)。大多数参与者对CVD危险因素的了解程度较低。这项研究表明,有必要进行大规模研究,以评估与心脏健康相关的知识以及这些人的实际需求和偏好。进行这样的研究将为这些服务不足的人制定基于需求的计划奠定基础,同时纳入他们的偏好和有助于他们参与心脏健康干预的策略。
    Limited information is available regarding the knowledge of Cardiovascular Disease (CVD) risk factors and the actual risk behaviors among African American (AA) older women living in rural areas of Alabama. A pilot study of needs assessment for CVD prevention behaviors was conducted to collect such data from rural AA women. This paper reports the quantitative part of the needs assessment of this pilot study. We recruited participants (N = 30) using convenience sampling. Data collection measures included: i) American Heart Association\'s CVD-related knowledge questionnaire, ii) Five Times Sit to Stand Test to measure dynamic balance and iii) Six minute walk test (6MWT) to assess exercise endurance iv) standard weighing scale to measure body weight and v) standard measurements scale to measure height.  Descriptive and inferential statistics were used to analyze the data. The majority (76%) of participants had hypertension (70%), diabetes (60%), poor balance (70%), and low exercise endurance (100%). Most of the participants had low knowledge related to CVD risk factors. This study demonstrated the need to conduct a large-scale study to assess knowledge related to heart health and the actual needs and preferences of these individuals. Conducting such a study would lay the foundation for developing a need-based program for these underserved individuals while incorporating their preferences and the strategies that would help engage them in a heart health intervention.
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  • 文章类型: Journal Article
    简介:欧洲指南建议在患有动脉粥样硬化性心血管疾病(ASCVD)的成年人(≥65岁)中实施降脂治疗(LLTs),并在老年人(≤75岁)中实施基于风险的一级预防。然而,它们在高龄成年人(>75岁)中的使用是有争议的,自由裁量,并以风险因素的存在为导向。这项回顾性研究的目的是评估高/极高风险老年人/极高龄成年人(65-74岁和≥75岁)在ST段抬高型心肌梗死(STEMI)中指南指导的LLT实施和低密度脂蛋白胆固醇(LDL-C)目标实现情况,并评估本地区老年人的循证护理服务。方法:所有STEMI患者在萨尔茨堡的大型三级中心接受治疗的LDL-C和总胆固醇,奥地利,2018-2020年,进行了筛选(n=910)。高风险/极高风险患者(n=369)根据欧洲指南标准进行分类,并按年龄分为队列:<65岁(n=152)。65-74岁(n=104),≥75岁(n=113)。结果:尽管处于高风险/非常高风险,以前LLT的使用在总队列中<40%,年龄没有显著差异。他汀单药治疗占主导地位;在整个队列中,20%-23%的老年/非常老年的成年人使用低/中等强度的染色,11%-13%使用高强度他汀类药物,4%的患者接受依泽替米贝治疗,没有人服用前蛋白转化酶枯草杆菌蛋白酶/kexin9型(PCSK9)抑制剂。在二级预防队列中,53%的老年/非常老年患者使用了先前的LLT。与<65岁的患者(29%;p=0.033)相比,年龄较大/年龄较大的ASCVD患者(43%和49%)达到LDL-C指标<70mg/dL的百分比明显更高,尽管只有22%和30%的老年组达到了更严格的LDL-C目标<55mg/dL。在64-74岁的老年人中,低LLT摄取(16%)的一级预防导致17%和10%的基于风险的LDL-C目标<70mg/dL和<55mg/dL,分别。初级和二级预防组中年龄最大的成年人(≥75岁)比老年人和年轻人更容易达到基于风险的目标。尽管主要接受低/中等强度他汀类药物单药治疗.结论:二级预防在我们地区次优。在STEMI发生时,不到一半的患有ASCVD的老年/非常老年的成年人达到LDL-C目标。提示LLT实施中严重的护理交付缺陷。在<75岁的高危/非常高危一级预防患者中,也观察到了基于风险的LLT启动的不足。这些患者中有10%-48%实现了基于风险的LDL-C目标。
    Introduction: European guidelines recommend the implementation of lipid-lowering therapies (LLTs) in adults (≥ 65 years) with established atherosclerotic cardiovascular disease (ASCVD) and for risk-based primary prevention in older adults (≤ 75 years), yet their use in very-old adults (> 75 years) is controversial, discretionary, and oriented on the presence of risk factors. The aim of this retrospective study is to assess guideline-directed LLT implementation and low-density lipoprotein cholesterol (LDL-C) target achievement in high-/very-high-risk older/very-old adults (65-74 and ≥ 75 years) at presentation for ST-segment elevation myocardial infarction (STEMI) and also to assess evidence-based care delivery to older adults in our region. Methods: All STEMI patients with available LDL-C and total cholesterol presenting for treatment at a large tertiary center in Salzburg, Austria, 2018-2020, were screened (n = 910). High-risk/very-high-risk patients (n = 369) were classified according to European guidelines criteria and divided into cohorts by age: < 65 years (n = 152), 65-74 years (n = 104), and ≥ 75 years (n = 113). Results: Despite being at high-/very-high-risk, prior LLT use was < 40% in the total cohort, with no significant difference by age. Statin monotherapy predominated; 20%-23% of older/very-old adults in the entire cohort were using low-/moderate-intensity stains, 11%-13% were using high-intensity statins, 4% were on ezetimibe therapy, and none were taking proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. In the secondary prevention cohort, 53% of older/very-old patients used prior LLTs. Significantly higher percentages of older/oldest ASCVD patients (43% and 49%) met LDL-C targets < 70 mg/dL compared to patients < 65 years (29%; p = 0.033), although just 22% and 30% of these older groups attained stricter LDL-C targets of < 55 mg/dL. Low LLT uptake (16%) among older adults aged 64-74 years for primary prevention resulted in 17% and 10% attainment of risk-based LDL-C targets < 70 mg/dL and < 55 mg/dL, respectively. Oldest adults (≥ 75 years) in both primary and secondary prevention groups more often met risk-based targets than older and younger adults, despite predominantly receiving low-/moderate-intensity statin monotherapy. Conclusion: Secondary prevention was sub-optimal in our region. Less than half of older/very-old adults with established ASCVD met LDL-C targets at the time of STEMI, suggesting severe care-delivery deficits in LLT implementation. Shortcomings in initiation of risk-based LLTs were also observed among high-/very-high-risk primary prevention patients < 75 years, with the achievement of risk-based LDL-C targets in 10%-48% of these patients.
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  • 文章类型: Journal Article
    肌肉减少性肥胖(SO)是一种临床疾病,其特征是肥胖增加,肌肉质量和功能下降,常见于老年人。然而,调查SO患病率的大多数研究并非基于目前的标准化诊断方法.因此,这项研究旨在使用欧洲临床营养与代谢学会(ESPEN)和欧洲肥胖研究协会(EASO)共识提出的不同工具来估计SO的患病率及其共识水平。在住院的重度肥胖老年人样本中。
    一项针对90名重度肥胖(体重指数≥35kg/m/²)的老年人(≥60岁)的横断面研究,寻求医院多学科减肥计划。使用五次重复的坐姿测试(5-SSt)和握力(HGS)评估骨骼肌功能。通过高百分比的脂肪质量(FM)来评估身体成分,低阑尾瘦质量(ALM/W),和骨骼肌质量(SMM/W),适应体重。在存在至少一种合并症的情况下评估SO的阶段,并对每个步骤采用特定的截止值。所有分析均根据性别和年龄范围进行。
    总样本中SO的患病率为23.3%,25.5%,31.1%,40.0%考虑5-SSt+FM+ALM/W的改变值,HGS+FM+ALM/W,5-SSt+FMSSM/W,和HGS+FM+SSM/W,分别。女性和老年亚组的患病率较高,无论诊断组合如何。使用总样本和所有亚组中的两种肌肉质量指数,肌肉功能测试(5-SSt与HGS)之间的一致性较弱。在总样本中,肌肉质量指数(SMM/W与ALM/W)之间观察到中等一致性,男性和年轻的老年人(使用5-SSt),和男性和年轻的老年人(使用HGS)的强有力的协议。
    观察到的患病率与其一致水平之间的差异加强了对类似人群进行新研究的需求,旨在更好地标准化SO评估。
    UNASSIGNED: Sarcopenic obesity (SO) is a clinical disorder characterized by increased adiposity and decreased muscle mass and function, commonly observed in older adults. However, most of the studies that investigated SO prevalence rates were not based on current standardized diagnostic methods. Thus, this study aims to estimate the prevalence rates of SO and their level of agreement using different instruments proposed by the European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO) Consensus, in a sample of hospitalized older adults with severe obesity.
    UNASSIGNED: A cross-sectional study with 90 older adults (≥ 60 years) with severe obesity (body mass index ≥ 35 kg/m/²) seeking an in-hospital multidisciplinary body weight reduction program. Skeletal muscle function was assessed using the five-repetition Sit-Stand test (5-SSt) and Handgrip Strength (HGS). Body composition was evaluated by high percentages of fat mass (FM), low appendicular lean mass (ALM/W), and skeletal muscle mass (SMM/W), adjusted to body weight. The stage of SO was assessed on the presence of at least one comorbidity and specific cut-offs were adopted for each step. All analyses were performed according to gender and age range.
    UNASSIGNED: The prevalence rates of SO in the total sample were 23.3%, 25.5%, 31.1%, and 40.0% considering altered values of 5-SSt+FM+ALM/W, HGS+FM+ALM/W, 5-SSt+FMSSM/W, and HGS+FM+SSM/W, respectively. Higher prevalence rates were observed among female and old elderly subgroups, regardless of the diagnostic combination. There were weak agreements between the muscle function tests (5-SSt versus HGS) using both muscle mass indexes in the total sample and all subgroups. Moderate agreements were observed between muscle mass indexes (SMM/W versus ALM/W) in the total sample, male and younger older adults (using 5-SSt), and strong agreements for men and younger older adults (using HGS).
    UNASSIGNED: The discrepancies observed between the prevalence rates and their levels of agreement reinforce the need for new studies in similar populations aiming for better standardization of SO assessment.
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