PDF(Pubmed)
Abstract：
In a Norwegian youth cohort followed from adolescence to young adulthood, bone mineral density (BMD) levels declined at the femoral neck and total hip from 16 to 27 years but continued to increase at the total body indicating a site-specific attainment of peak bone mass.
OBJECTIVE: To examine longitudinal trends in bone mineral density (BMD) levels in Norwegian adolescents into young adulthood.
METHODS: In a prospective cohort design, we followed 980 adolescents (473 (48%) females) aged 16-19 years into adulthood (age of 26-29) on three occasions: 2010-2011 (Fit Futures 1 (FF1)), 2012-2013 (FF2), and 2021-2022 (FF3), measuring BMD (g/cm2) at the femoral neck, total hip, and total body with dual x-ray absorptiometry (DXA). We used linear mixed models to examine longitudinal BMD changes from FF1 to FF3.
RESULTS: From the median age of 16 years (FF1), femoral neck BMD (mean g/cm2 (95% CI)) slightly increased in females from 1.070 (1.059-1.082) to 1.076 (1.065-1.088, p = 0.015) at the median age of 18 years (FF2) but declined to 1.041 (1.029-1.053, p < 0.001) at the median age of 27 years (FF3). Similar patterns were observed in males: 16 years, 1.104 (1.091-1.116); 27 years, 1.063 (1.050-1.077, p < 0.001); and for the total hip in both sexes (both p < 0.001). Total body BMD increased from age 16 to 27 years in both sexes (females: 16 years, 1.141 (1.133-1.148); 27 years, 1.204 (1.196-1.212), p < 0.001; males: 16 years, 1.179 (1.170-1.188); 27 years, 1.310 (1.296-1.315), p < 0.001).
CONCLUSIONS: BMD levels increased from 16 to 18 years at the femoral and total hip sites in young Norwegian females and males, and a small decline was observed at the femoral sites when the participants were followed up to 27 years. Total body BMD continued to increase from adolescence to young adulthood.
OBJECTIVE: To examine longitudinal trends in bone mineral density (BMD) levels in Norwegian adolescents into young adulthood.
METHODS: In a prospective cohort design, we followed 980 adolescents (473 (48%) females) aged 16-19 years into adulthood (age of 26-29) on three occasions: 2010-2011 (Fit Futures 1 (FF1)), 2012-2013 (FF2), and 2021-2022 (FF3), measuring BMD (g/cm2) at the femoral neck, total hip, and total body with dual x-ray absorptiometry (DXA). We used linear mixed models to examine longitudinal BMD changes from FF1 to FF3.
RESULTS: From the median age of 16 years (FF1), femoral neck BMD (mean g/cm2 (95% CI)) slightly increased in females from 1.070 (1.059-1.082) to 1.076 (1.065-1.088, p = 0.015) at the median age of 18 years (FF2) but declined to 1.041 (1.029-1.053, p < 0.001) at the median age of 27 years (FF3). Similar patterns were observed in males: 16 years, 1.104 (1.091-1.116); 27 years, 1.063 (1.050-1.077, p < 0.001); and for the total hip in both sexes (both p < 0.001). Total body BMD increased from age 16 to 27 years in both sexes (females: 16 years, 1.141 (1.133-1.148); 27 years, 1.204 (1.196-1.212), p < 0.001; males: 16 years, 1.179 (1.170-1.188); 27 years, 1.310 (1.296-1.315), p < 0.001).
CONCLUSIONS: BMD levels increased from 16 to 18 years at the femoral and total hip sites in young Norwegian females and males, and a small decline was observed at the femoral sites when the participants were followed up to 27 years. Total body BMD continued to increase from adolescence to young adulthood.
摘要：
在从青春期到成年的挪威青年队列中，从16年到27年，股骨颈和全髋关节的骨矿物质密度（BMD）水平下降，但在全身继续增加，表明特定部位达到了峰值骨量。
目的：研究挪威青少年成年期骨密度（BMD）水平的纵向趋势。
方法：在前瞻性队列设计中，我们跟踪了980名16-19岁的青少年（473（48％）女性）到成年（26-29岁）三次：2010-2011（FitFutures1（FF1）），2012-2013（FF2），和2021-2022（FF3），测量股骨颈的BMD（g/cm2），全髋关节,和全身双X射线吸收法（DXA）。我们使用线性混合模型来检查从FF1到FF3的纵向BMD变化。
结果：从中位年龄16岁（FF1）开始，女性股骨颈BMD(平均g/cm2(95%CI))在中位年龄18岁(FF2)时从1.070(1.059-1.082)略微增加至1.076(1.065-1.088,p=0.015),但在中位年龄27岁(FF3)时下降至1.041(1.029-1.053,p<0.001).在男性中观察到类似的模式：16岁，1.104（1.091-1.116）；27年，1.063（1.050-1.077，p<0.001）；对于两种性别的全髋关节（均p<0.001）。男女的总身体BMD从16岁增加到27岁（女性：16岁，1.141（1.133-1.148）；27年，1.204(1.196-1.212),p<0.001；男性：16岁，1.179（1.170-1.188）；27年，1.310(1.296-1.315),p<0.001)。
结论：年轻的挪威女性和男性的股骨和全髋关节部位的BMD水平从16岁增加到18岁，在对参与者进行长达27年的随访时，在股骨部位观察到小幅下降。从青春期到成年，全身BMD持续增加。
目的：研究挪威青少年成年期骨密度（BMD）水平的纵向趋势。
方法：在前瞻性队列设计中，我们跟踪了980名16-19岁的青少年（473（48％）女性）到成年（26-29岁）三次：2010-2011（FitFutures1（FF1）），2012-2013（FF2），和2021-2022（FF3），测量股骨颈的BMD（g/cm2），全髋关节,和全身双X射线吸收法（DXA）。我们使用线性混合模型来检查从FF1到FF3的纵向BMD变化。
结果：从中位年龄16岁（FF1）开始，女性股骨颈BMD(平均g/cm2(95%CI))在中位年龄18岁(FF2)时从1.070(1.059-1.082)略微增加至1.076(1.065-1.088,p=0.015),但在中位年龄27岁(FF3)时下降至1.041(1.029-1.053,p<0.001).在男性中观察到类似的模式：16岁，1.104（1.091-1.116）；27年，1.063（1.050-1.077，p<0.001）；对于两种性别的全髋关节（均p<0.001）。男女的总身体BMD从16岁增加到27岁（女性：16岁，1.141（1.133-1.148）；27年，1.204(1.196-1.212),p<0.001；男性：16岁，1.179（1.170-1.188）；27年，1.310(1.296-1.315),p<0.001)。
结论：年轻的挪威女性和男性的股骨和全髋关节部位的BMD水平从16岁增加到18岁，在对参与者进行长达27年的随访时，在股骨部位观察到小幅下降。从青春期到成年，全身BMD持续增加。
