Abstract：
While metabolic acidosis is one of the most common complications in patients with chronic kidney disease (CKD), there are several uncommon etiologies that are challenging to diagnose. Here, we describe a patient on peritoneal dialysis who developed high anion gap metabolic acidosis secondary to acquired 5-oxoprolinemia from acetaminophen use. While CKD is a known risk factor for developing this potentially serious complication, this case further highlights how 5-oxoproline accumulation can occur, even with therapeutic dosing of acetaminophen.
摘要：
代谢性酸中毒是慢性肾脏病(CKD)患者最常见的并发症之一,有几种不常见的病因难以诊断.这里,我们描述了一名腹膜透析患者，该患者因使用对乙酰氨基酚而继发于获得性5-氧代脯氨酸血症，出现了高阴离子间隙代谢性酸中毒。虽然CKD是发生这种潜在严重并发症的已知危险因素，这个案例进一步强调了5-氧代脯氨酸的积累是如何发生的，即使是对乙酰氨基酚的治疗剂量。
