%0 Journal Article
%T Acetaminophen induced high anion gap metabolic acidosis: a potentially under-recognized consequence from a common medication.
%A Gaur D
%A Michalopulos MG
%A Drake KA
%A Gattineni J
%J Pediatr Nephrol
%V 0
%N 0
%D 2024 Jul 2
%M 38954037
%F 3.651
%R 10.1007/s00467-024-06396-4
%X While metabolic acidosis is one of the most common complications in patients with chronic kidney disease (CKD), there are several uncommon etiologies that are challenging to diagnose. Here, we describe a patient on peritoneal dialysis who developed high anion gap metabolic acidosis secondary to acquired 5-oxoprolinemia from acetaminophen use. While CKD is a known risk factor for developing this potentially serious complication, this case further highlights how 5-oxoproline accumulation can occur, even with therapeutic dosing of acetaminophen.