{Reference Type}: Journal Article
{Title}: Acetaminophen induced high anion gap metabolic acidosis: a potentially under-recognized consequence from a common medication.
{Author}: Gaur D;Michalopulos MG;Drake KA;Gattineni J;
{Journal}: Pediatr Nephrol
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 2
{Factor}: 3.651
{DOI}: 10.1007/s00467-024-06396-4
{Abstract}: While metabolic acidosis is one of the most common complications in patients with chronic kidney disease (CKD), there are several uncommon etiologies that are challenging to diagnose. Here, we describe a patient on peritoneal dialysis who developed high anion gap metabolic acidosis secondary to acquired 5-oxoprolinemia from acetaminophen use. While CKD is a known risk factor for developing this potentially serious complication, this case further highlights how 5-oxoproline accumulation can occur, even with therapeutic dosing of acetaminophen.