PDF(Pubmed)
Abstract：
UNASSIGNED: Children with Congenital Adrenal Hyperplasia (CAH) have a higher chance of hypertension. The likelihood of hypertension is higher in CAH children who get fludrocortisone medication and have an over-suppression. Plasma renin activity (PRA) is a sensitive indicator when the fludrocortisone dose is insufficient. The objective of this study is to assess the relationship between plasma renin activity with hypertension in 21-hydroxylase-deficient (21-OHD) CAH children.
UNASSIGNED: This cross-sectional observational analytical study was conducted in 2019 at the Pediatric Endocrinology Outpatient Clinic in Dr. Cipto Mangunkusumo Hospital (RSCM), Jakarta, Indonesia. The subjects were 21-OHD CAH children, aged >6 months to 18 years who had already taken hydrocortisone with or without fludrocortisone for at least 6 months, and were divided into hypertension and non-hypertension groups. The subjects were selected by a consecutive sampling method. Data was analyzed using SPSS software (version 23.0) with unpaired t test analysis and multiple logistic regression test. Statistical significance was achieved if P<0.05.
UNASSIGNED: Forty 21-OHD CAH patients were included, and 20 subjects (50%) had hypertension. A higher incidence of hypertension was found in salt-wasting CAH than in simple virilizing types (59.3% vs 30.8%). There was a significant mean difference in PRA levels between hypertension and non-hypertension groups in salt-wasting patients (P=0.016). A significant difference between the last dose of hydrocortisone with the number of hypertension patients in salt-wasting patients (P=0.032) was found, and low PRA levels showed a 1.09 times higher risk of hypertension.
UNASSIGNED: Children with salt-wasting CAH with low PRA levels had a higher risk of getting hypertension.
UNASSIGNED: This cross-sectional observational analytical study was conducted in 2019 at the Pediatric Endocrinology Outpatient Clinic in Dr. Cipto Mangunkusumo Hospital (RSCM), Jakarta, Indonesia. The subjects were 21-OHD CAH children, aged >6 months to 18 years who had already taken hydrocortisone with or without fludrocortisone for at least 6 months, and were divided into hypertension and non-hypertension groups. The subjects were selected by a consecutive sampling method. Data was analyzed using SPSS software (version 23.0) with unpaired t test analysis and multiple logistic regression test. Statistical significance was achieved if P<0.05.
UNASSIGNED: Forty 21-OHD CAH patients were included, and 20 subjects (50%) had hypertension. A higher incidence of hypertension was found in salt-wasting CAH than in simple virilizing types (59.3% vs 30.8%). There was a significant mean difference in PRA levels between hypertension and non-hypertension groups in salt-wasting patients (P=0.016). A significant difference between the last dose of hydrocortisone with the number of hypertension patients in salt-wasting patients (P=0.032) was found, and low PRA levels showed a 1.09 times higher risk of hypertension.
UNASSIGNED: Children with salt-wasting CAH with low PRA levels had a higher risk of getting hypertension.
摘要：
■患有先天性肾上腺增生（CAH）的儿童患高血压的机会更高。在接受氟氢可的松药物治疗并过度抑制的CAH儿童中，高血压的可能性更高。当氟氢可的松剂量不足时，血浆肾素活性（PRA）是一个敏感指标。这项研究的目的是评估21-羟化酶缺陷（21-OHD）CAH儿童血浆肾素活性与高血压之间的关系。
■这项横断面观察性分析研究于2019年在CiptoMangunkusumo医生医院（RSCM）的儿科内分泌门诊进行，雅加达,印度尼西亚。受试者是21-OHDCAH儿童，年龄>6个月至18岁，已经服用或不服用氟氢可的松至少6个月的氢化可的松，分为高血压组和非高血压组。通过连续取样方法选择受试者。采用SPSS软件(23.0版)对数据进行非配对t检验和多因素logistic回归分析。如果P<0.05,则达到统计学显著性。
■纳入40名21-OHDCAH患者，20名受试者（50％）患有高血压。在食盐性CAH中发现高血压的发生率高于简单的男性化类型（59.3％对30.8％）。在盐消耗患者中，高血压组和非高血压组之间的PRA水平存在显着差异（P=0.016）。发现最后剂量的氢化可的松与盐消耗患者的高血压患者人数之间存在显着差异（P=0.032），低PRA水平显示高血压风险高1.09倍。
■PRA水平低的盐消耗型CAH儿童患高血压的风险更高。
■这项横断面观察性分析研究于2019年在CiptoMangunkusumo医生医院（RSCM）的儿科内分泌门诊进行，雅加达,印度尼西亚。受试者是21-OHDCAH儿童，年龄>6个月至18岁，已经服用或不服用氟氢可的松至少6个月的氢化可的松，分为高血压组和非高血压组。通过连续取样方法选择受试者。采用SPSS软件(23.0版)对数据进行非配对t检验和多因素logistic回归分析。如果P<0.05,则达到统计学显著性。
■纳入40名21-OHDCAH患者，20名受试者（50％）患有高血压。在食盐性CAH中发现高血压的发生率高于简单的男性化类型（59.3％对30.8％）。在盐消耗患者中，高血压组和非高血压组之间的PRA水平存在显着差异（P=0.016）。发现最后剂量的氢化可的松与盐消耗患者的高血压患者人数之间存在显着差异（P=0.032），低PRA水平显示高血压风险高1.09倍。
■PRA水平低的盐消耗型CAH儿童患高血压的风险更高。
