关键词: Drug delivery Microneedle Neurological disease

Mesh : Needles Humans Drug Delivery Systems / methods Nervous System Diseases / drug therapy Animals Microinjections / methods Administration, Cutaneous

来  源:   DOI:10.1016/j.ijpharm.2024.124400

Abstract:
Neurological disorders, including brain injury, brain tumors, and neurodegenerative diseases, rank as the second leading cause of death worldwide. Exploring effective new treatments for neurological disorders has long been a hot research issue in clinical practice. Recently, microneedles (MNs) have attracted much attention due to their designation as a \"painless and non-invasive\" novel transdermal delivery method, characterized by their biocompatibility and sustainability. The advantages of MNs open an avenue for potential therapeutic interventions targeting neurological disorders. This review presents a concise overview of progress in the field of MNs, with highlights on the application in the treatment of neurological disorders. Notably, trends in the development of MNs and future challenges are also discussed.
摘要:
神经系统疾病,包括脑损伤,脑肿瘤,和神经退行性疾病,是全球第二大死因。探索有效治疗神经系统疾病的新方法一直是临床实践中的研究热点。最近,微针(MNs)因其被称为“无痛、无创”的新型透皮给药方法而备受关注,以其生物相容性和可持续性为特征。MNs的优势为针对神经系统疾病的潜在治疗干预开辟了途径。这篇综述简要概述了MNs领域的进展,重点介绍了在治疗神经系统疾病中的应用。值得注意的是,讨论了MNs的发展趋势和未来面临的挑战。
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