细胞死亡是维持体内稳态的最重要机制之一。铁凋亡和焦亡是坏死样细胞死亡的形式。这些细胞死亡模式在癌症的病理生理学中起着关键作用。心血管,神经系统疾病,和其他病症。过渡金属是所有生物体中丰富的元素。本文总结了铁凋亡和焦凋亡途径及其与重要过渡金属的联系,即锌(Zn),铜(Cu),钼(Mo),铅(Pb),钴(Co),铁(Fe),镉(Cd),镍(Ni),汞(Hg),铀(U),铂(Pt),一个关键因素,硒(Se)。作者旨在总结本主题的最新知识。在这次审查中,在过渡金属的铁凋亡和焦凋亡改变中,最常见的模式被分类和强调。特别注意锌,因为收集的数据支持其在铁凋亡和焦凋亡中的双重作用性质。所有发现都与涉及上述金属的主要生化途径的简要描述一起呈现,并在随附的综合图中可视化。这项工作得出的结论是,所研究的金属体内稳态的大多数破坏都会影响细胞命运,在改变途径的复杂系统中影响细胞的死亡和存活。因此,本总结为进一步研究开辟了空间。
Cell death is one of the most important mechanisms of maintaining homeostasis in our body. Ferroptosis and pyroptosis are forms of necrosis-like cell death. These cell death modalities play key roles in the pathophysiology of cancer, cardiovascular, neurological diseases, and other pathologies. Transition metals are abundant group of elements in all living organisms. This paper presents a summary of ferroptosis and pyroptosis pathways and their connection to significant transition metals, namely zinc (Zn), copper (Cu), molybdenum (Mo), lead (Pb), cobalt (Co), iron (Fe), cadmium (Cd), nickel (Ni), mercury (Hg), uranium (U), platinum (Pt), and one crucial element, selenium (Se). Authors aim to summarize the up-to-date knowledge of this topic.In this review, there are categorized and highlighted the most common patterns in the alterations of ferroptosis and pyroptosis by transition metals. Special attention is given to zinc since collected data support its dual nature of action in both ferroptosis and pyroptosis. All findings are presented together with a brief description of major biochemical pathways involving mentioned metals and are visualized in attached comprehensive figures.This work concludes that the majority of disruptions in the studied metals\' homeostasis impacts cell fate, influencing both death and survival of cells in the complex system of altered pathways. Therefore, this summary opens up the space for further research.