Abstract：
BACKGROUND: The pro-inflammatory adipokine resistin is known to be related to obesity, insulin resistance, and inflammation. Resistin\'s significance in the etiology of inflammatory illnesses, such as psoriasis, is explored herein. We examined the link between resistin gene polymorphisms (-420 C>G and +299 G>A) and psoriasis in the Turkish population.
METHODS: In this study, we examined 107 patients with psoriasis and 103 healthy controls. Resistin -420 C>G (rs1862513) and +299 G>A (rs3745367) gene polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
RESULTS: In patients with psoriasis, the frequency of the resistin -420 CG genotype was meaningfully lower than in the controls. In comparison with the controls, the resistin +299 GA genotype and A allele frequencies were significantly higher. The Resistin -420 CG genotype significantly reduced the risk of psoriasis incidence, while the resistin +299 GA genotype and A allele were found to be associated with a higher risk of psoriasis.
CONCLUSIONS: In the Turkish community, resistin gene polymorphisms at -420 C>G and +299 G>A may exert an important influence on psoriasis etiology and susceptibility.
METHODS: In this study, we examined 107 patients with psoriasis and 103 healthy controls. Resistin -420 C>G (rs1862513) and +299 G>A (rs3745367) gene polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
RESULTS: In patients with psoriasis, the frequency of the resistin -420 CG genotype was meaningfully lower than in the controls. In comparison with the controls, the resistin +299 GA genotype and A allele frequencies were significantly higher. The Resistin -420 CG genotype significantly reduced the risk of psoriasis incidence, while the resistin +299 GA genotype and A allele were found to be associated with a higher risk of psoriasis.
CONCLUSIONS: In the Turkish community, resistin gene polymorphisms at -420 C>G and +299 G>A may exert an important influence on psoriasis etiology and susceptibility.
摘要：
背景：已知促炎脂肪因子抵抗素与肥胖有关，胰岛素抵抗，和炎症。抵抗素在炎症性疾病的病因学中的意义，比如牛皮癣,在这里探索。我们检查了土耳其人群中抵抗素基因多态性（-420C>G和299G>A）与牛皮癣之间的联系。
方法：在本研究中，我们检查了107例银屑病患者和103例健康对照。通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）确定抵抗素-420C>G（rs1862513）和299G>A（rs3745367）基因多态性。
结果：在银屑病患者中，抵抗素-420CG基因型的频率明显低于对照组。与控件相比，抵抗素299GA基因型和A等位基因频率明显较高。抵抗素-420CG基因型显着降低银屑病发病率的风险，而抵抗素299GA基因型和A等位基因与银屑病的高风险相关。
结论：在土耳其社区，-420C>G和299G>A的抵抗素基因多态性可能对银屑病的病因和易感性有重要影响。
方法：在本研究中，我们检查了107例银屑病患者和103例健康对照。通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）确定抵抗素-420C>G（rs1862513）和299G>A（rs3745367）基因多态性。
结果：在银屑病患者中，抵抗素-420CG基因型的频率明显低于对照组。与控件相比，抵抗素299GA基因型和A等位基因频率明显较高。抵抗素-420CG基因型显着降低银屑病发病率的风险，而抵抗素299GA基因型和A等位基因与银屑病的高风险相关。
结论：在土耳其社区，-420C>G和299G>A的抵抗素基因多态性可能对银屑病的病因和易感性有重要影响。
