目的:成人体重指数(BMI)与脂联素水平成反比,而胰岛素,C反应蛋白(CRP),白细胞介素6(IL-6),抵抗素和肿瘤坏死因子-α(TNF-α)与BMI升高有关。在西班牙裔儿科人群中,这些生物标志物与BMI的作用和关系鲜为人知。因此,本研究的目的是在田纳西州东北部的西班牙裔青年人群中,在控制几种社会人口统计学因素的同时,检验炎症标志物与超重/肥胖几率的相关性.
方法:高度,体重,人口统计信息,我们收集了2015-2016年在田纳西州东北部一家大型社区卫生中心招募的107名2~10岁西班牙裔儿童的血液样本.这项研究的数据在2022年进行了访问和分析。进行了多变量logistic回归以评估脂联素,胰岛素,抵抗素,CRP,TNF-α,和IL-6,超重/肥胖与有一个健康的(正常的)体重。
结果:与健康体重儿童相比,超重/肥胖西班牙裔儿童的脂联素水平明显较低(p=0.0144)。血清脂联素每增加一个单位,超重/肥胖的几率降低4%。与健康体重儿童相比,超重/肥胖西班牙裔儿童的胰岛素水平明显更高(p=0.0048)。血清胰岛素每增加一个单位,超重/肥胖的几率增加7%。Resistin,IL-6,TNF-α,在该人群中,CRP与超重/肥胖无显著相关性.
结论:脂联素在西班牙裔青年中的表现与在其他儿科人群中相似,在检查该人群的代谢健康状况时,可能使其成为有价值的标记。
OBJECTIVE: Body mass index (BMI) is inversely proportional with adiponectin levels among adults, while insulin, C-reactive protein (CRP), interleukin 6 (IL-6),
resistin and tumor necrosis factor-alpha (TNF-α) have been linked with elevated BMI. The role and relation of these biomarkers with BMI among a Hispanic pediatric population are less known. Thus, the objective of this study was to examine the association of inflammatory markers with the odds of overweight/obesity while controlling for several sociodemographic factors among a Hispanic youth population in Northeast Tennessee.
METHODS: Height, weight, demographic information, and blood samples were collected from 107 Hispanic children aged 2 to 10 years recruited at a large community health center in 2015-2016 in Northeast Tennessee. Data for this research were accessed and analyzed in 2022. Multivariable logistic regression was conducted to assess the relations between adiponectin, insulin,
resistin, CRP, TNF-α, and IL-6, and overweight/obesity vs. having a healthy (normal) weight.
RESULTS: Adiponectin levels were significantly lower among overweight/obese Hispanic children (p = 0.0144) compared to healthy weight children. The odds of overweight/obesity decreased by 4% for every one-unit increase in serum adiponectin. Insulin levels were significantly higher among overweight/obese Hispanic children compared to healthy weight children (p = 0.0048). The odds of overweight/obesity increased by 7% for every one-unit increase in serum insulin.
Resistin, IL-6, TNF-α, and CRP were not significantly associated with overweight/obesity in this population.
CONCLUSIONS: Adiponectin behaves similarly in Hispanic youth as it does in other pediatric populations, possibly making it a valuable marker when examining metabolic health status in this population.