Abstract：
Purpose: Prurigo nodularis (PN) is a skin disease characterized by intensely itchy skin nodules and is associated with a significant healthcare resource utilization (HCRU). This study aimed to estimate the HCRU of patients in England with PN overall and moderate-to-severe PN (MSPN) in particular.
Methods: This retrospective cohort study used data from the Clinical Practice Research Datalink and Hospital Episode Statistics in England. Patients with Mild PN (MiPN) were matched to patients with MSPN by age and gender for the primary analysis. Patients were enrolled in the study between 1st April 2007 and 1st March 2019. All-cause HCRU was calculated, including primary and secondary care contacts and costs (cost-year 2022).
Results: Of 23,522 identified patients, 8,933 met the inclusion criteria, with a primary matched cohort of 2,479 PN patients. During follow up, the matched cohort\'s primary care visits were 21.27 per patient year (PPY) for MSPN group and 11.35 PPY for MiPN group. Any outpatient visits were 10.72 PPY and 4.87 PPY in MSPN and MiPN groups, respectively. Outpatient dermatology visits were 1.96 PPY and 1.14 PPY in MSPN and MiPN groups, respectively.
Conclusion: PN, especially MSPN, has a high HCRU burden in England, highlighting the need for new and improved disease management treatments.
Methods: This retrospective cohort study used data from the Clinical Practice Research Datalink and Hospital Episode Statistics in England. Patients with Mild PN (MiPN) were matched to patients with MSPN by age and gender for the primary analysis. Patients were enrolled in the study between 1st April 2007 and 1st March 2019. All-cause HCRU was calculated, including primary and secondary care contacts and costs (cost-year 2022).
Results: Of 23,522 identified patients, 8,933 met the inclusion criteria, with a primary matched cohort of 2,479 PN patients. During follow up, the matched cohort\'s primary care visits were 21.27 per patient year (PPY) for MSPN group and 11.35 PPY for MiPN group. Any outpatient visits were 10.72 PPY and 4.87 PPY in MSPN and MiPN groups, respectively. Outpatient dermatology visits were 1.96 PPY and 1.14 PPY in MSPN and MiPN groups, respectively.
Conclusion: PN, especially MSPN, has a high HCRU burden in England, highlighting the need for new and improved disease management treatments.
摘要：
目的：结节性痒疹（PN）是一种皮肤疾病，其特征是皮肤结节严重发痒，与重要的医疗保健资源利用（HCRU）有关。这项研究旨在评估英格兰PN总体和中度至重度PN（MSPN）患者的HCRU。
方法：这项回顾性队列研究使用了来自英国临床实践研究数据链和医院事件统计的数据。在主要分析中，将轻度PN（MiPN）患者与MSPN患者的年龄和性别进行匹配。患者在2007年4月1日至2019年3月1日期间纳入研究。计算了全因HCCU,包括初级和二级保健接触者和费用（成本年2022）。
结果：在23,522名确定的患者中，8,933符合纳入标准，与2,479名PN患者的主要匹配队列。随访期间,MSPN组和MiPN组的匹配队列初级护理访视次数分别为21.27/患者年(PPY)和11.35PPY.MSPN和MiPN组的任何门诊量为10.72PPY和4.87PPY，分别。MSPN和MiPN组的门诊皮肤科访视为1.96PPY和1.14PPY，分别。
结论：PN，尤其是MSPN,在英国有很高的HCCU负担，强调需要新的和改进的疾病管理治疗。
方法：这项回顾性队列研究使用了来自英国临床实践研究数据链和医院事件统计的数据。在主要分析中，将轻度PN（MiPN）患者与MSPN患者的年龄和性别进行匹配。患者在2007年4月1日至2019年3月1日期间纳入研究。计算了全因HCCU,包括初级和二级保健接触者和费用（成本年2022）。
结果：在23,522名确定的患者中，8,933符合纳入标准，与2,479名PN患者的主要匹配队列。随访期间,MSPN组和MiPN组的匹配队列初级护理访视次数分别为21.27/患者年(PPY)和11.35PPY.MSPN和MiPN组的任何门诊量为10.72PPY和4.87PPY，分别。MSPN和MiPN组的门诊皮肤科访视为1.96PPY和1.14PPY，分别。
结论：PN，尤其是MSPN,在英国有很高的HCCU负担，强调需要新的和改进的疾病管理治疗。
