Abstract：
The ability of pathogenic bacteria to evade antibiotic treatment is an intricate and multifaceted phenomenon. Over the years, treatment failure among patients due to determinants of antimicrobial resistance (AMR) has been the focal point for the research and development of new therapeutic agents. However, the survival of bacteria by persisting under antibiotic stress has largely been overlooked. Bacterial persisters are a subpopulation of sensitive bacterial cells exhibiting a noninheritable drug-tolerant phenotype. They are linked to the recalcitrance of infections in healthcare settings, in turn giving rise to AMR variants. The importance of bacterial persistence in recurring infections has been firmly recognized. Fundamental work over the past decade has highlighted numerous unique tolerance factors contributing to the persister phenotype in many clinically relevant pathogens. This review summarizes contributing factors that could aid in developing new strategies against bacterial antibiotic persisters.
摘要：
病原菌逃避抗生素治疗的能力是一个复杂而多方面的现象。多年来,由于抗菌素耐药性（AMR）的决定因素而导致的患者治疗失败一直是研究和开发新治疗剂的重点。然而,细菌在抗生素胁迫下的存活在很大程度上被忽视了。细菌持久性是表现出非遗传性药物耐受性表型的敏感细菌细胞亚群。它们与医疗机构中感染的顽抗有关，反过来又产生了AMR变体。细菌持久性在复发性感染中的重要性已得到充分认识。在过去的十年中，基础工作强调了许多独特的耐受性因素，这些因素有助于许多临床相关病原体的持久性表型。这篇综述总结了有助于开发针对细菌抗生素持久性药物的新策略的因素。
