Abstract：
UNASSIGNED: Yasunari nodules are choroidal lesions observed in patients diagnosed with neurofibromatosis type 1 (NF-1) and characterized by relatively irregular dome-shaped, plaque-like, or patchy boundaries. The present study examines the multimodal imaging characteristics of Yasunari nodules and their value in the diagnosis of NF-1.
UNASSIGNED: Medical records including optical coherence tomography (OCT), enhanced depth imaging OCT, infrared reflectance (IR) imaging, OCT angiography, and color fundus images of NF-1 patients who were examined at the Department of Ophthalmology in Dokuz Eylül University Faculty of Medicine between January 2022 and December 2023 were retrospectively reviewed for the presence of Yasunari nodules.
UNASSIGNED: A total of 54 eyes of 27 patients were included in the study. At least one choroidal nodule was detected on IR imaging in 52 eyes (96.3%). In 31 (72.1%) of the 43 eyes (79.6%) with available high-quality OCT angiography images, choroidal nodules were observed as areas showing a flow deficit in the choriocapillaris layer. Of the total 54 eyes included, Lisch nodules without choroidal nodules were observed in 2 eyes (3.7%). In 16 eyes (29.6%), Lisch nodules were not detected despite the presence of choroidal nodules. Both Lisch nodules and choroidal nodules were detected in the other 36 eyes (66.7%).
UNASSIGNED: Yasunari nodules are frequently observed in NF-1 cases and can be easily detected with multimodal imaging techniques, especially IR imaging. The ability to visualize choroidal nodules before the appearance of Lisch nodules demonstrates the importance of Yasunari nodules in the diagnosis of NF-1.
UNASSIGNED: Medical records including optical coherence tomography (OCT), enhanced depth imaging OCT, infrared reflectance (IR) imaging, OCT angiography, and color fundus images of NF-1 patients who were examined at the Department of Ophthalmology in Dokuz Eylül University Faculty of Medicine between January 2022 and December 2023 were retrospectively reviewed for the presence of Yasunari nodules.
UNASSIGNED: A total of 54 eyes of 27 patients were included in the study. At least one choroidal nodule was detected on IR imaging in 52 eyes (96.3%). In 31 (72.1%) of the 43 eyes (79.6%) with available high-quality OCT angiography images, choroidal nodules were observed as areas showing a flow deficit in the choriocapillaris layer. Of the total 54 eyes included, Lisch nodules without choroidal nodules were observed in 2 eyes (3.7%). In 16 eyes (29.6%), Lisch nodules were not detected despite the presence of choroidal nodules. Both Lisch nodules and choroidal nodules were detected in the other 36 eyes (66.7%).
UNASSIGNED: Yasunari nodules are frequently observed in NF-1 cases and can be easily detected with multimodal imaging techniques, especially IR imaging. The ability to visualize choroidal nodules before the appearance of Lisch nodules demonstrates the importance of Yasunari nodules in the diagnosis of NF-1.
摘要：
■Yasunari结节是在诊断为1型神经纤维瘤病（NF-1）的患者中观察到的脉络膜病变，其特征是相对不规则的圆顶形，斑块状,或零散的界限。本研究探讨了Yasunari结节的多模态影像学特征及其在NF-1诊断中的价值。
■包括光学相干断层扫描（OCT）在内的医疗记录，增强深度成像OCT,红外反射(IR)成像,OCT血管造影,对2022年1月至2023年12月在DokuzEylül大学医学院眼科检查的NF-1患者的眼底彩色图像进行了回顾性分析,以确定是否存在Yasunari结节.
■本研究共纳入27例患者的54只眼。在52只眼（96.3％）的IR成像中至少检测到一个脉络膜结节。在获得高质量OCT血管造影图像的43只眼睛（79.6%）中，有31只（72.1%），脉络膜结节是脉络膜毛细血管层显示流量不足的区域。在总共54只眼睛中，2只眼（3.7％）观察到无脉络膜结节的Lisch结节。16只眼睛（29.6%）尽管存在脉络膜结节，但未检测到Lisch结节。在其他36只眼中检测到Lisch结节和脉络膜结节（66.7％）。
■在NF-1病例中经常观察到Yasunari结节，可以通过多模态成像技术轻松检测到，尤其是红外成像。在出现Lisch结节之前可视化脉络膜结节的能力证明了Yasunari结节在NF-1诊断中的重要性。
■包括光学相干断层扫描（OCT）在内的医疗记录，增强深度成像OCT,红外反射(IR)成像,OCT血管造影,对2022年1月至2023年12月在DokuzEylül大学医学院眼科检查的NF-1患者的眼底彩色图像进行了回顾性分析,以确定是否存在Yasunari结节.
■本研究共纳入27例患者的54只眼。在52只眼（96.3％）的IR成像中至少检测到一个脉络膜结节。在获得高质量OCT血管造影图像的43只眼睛（79.6%）中，有31只（72.1%），脉络膜结节是脉络膜毛细血管层显示流量不足的区域。在总共54只眼睛中，2只眼（3.7％）观察到无脉络膜结节的Lisch结节。16只眼睛（29.6%）尽管存在脉络膜结节，但未检测到Lisch结节。在其他36只眼中检测到Lisch结节和脉络膜结节（66.7％）。
■在NF-1病例中经常观察到Yasunari结节，可以通过多模态成像技术轻松检测到，尤其是红外成像。在出现Lisch结节之前可视化脉络膜结节的能力证明了Yasunari结节在NF-1诊断中的重要性。
