Abstract：
OBJECTIVE: To investigate the relationship between continuous glucose monitoring (CGM)-derived glucometrics and metabolic dysfunction-associated steatotic liver disease (MASLD) in type 1 diabetes (T1D).
METHODS: A cross-sectional study collecting data on anthropometrics, glucometrics and MASLD in adults with T1D using a CGM device was conducted. MASLD was assessed by abdominal ultrasound and the presence of at least one cardiometabolic criterion. Backward multivariable logistic regression models were applied to define variables independently associated with MASLD.
RESULTS: A total of 302 consecutive participants were included (median age 49 [34-61] years, male sex 58%, median diabetes duration 29 [17-38] years, mean time in range [TIR] 55% ± 16%). MASLD was present in 17% of cases, and 32% had metabolic syndrome (MetS). MetS was significantly more prevalent in the MASLD group (65% vs. 25%, P < .0001). TIR (P = .038) and time below range (TBR) (P = .032) were lower and time above range (TAR) was higher (P = .006), whereas HbA1c did not reach significance (P = .068). No differences were found for the glycaemia risk index. TIR (P = .028), TAR (P = .007), TBR (P = .036), waist circumference (P < .001) and systolic blood pressure (P = .029) were independently associated with MASLD, while sex, age, aspartate aminotransferase/alanine aminotransferase ratio, gamma-glutamyl transferase, high-density lipoprotein cholesterol and triglycerides were not.
CONCLUSIONS: TIR, TAR, TBR, waist circumference and systolic blood pressure were independently associated with MASLD.
METHODS: A cross-sectional study collecting data on anthropometrics, glucometrics and MASLD in adults with T1D using a CGM device was conducted. MASLD was assessed by abdominal ultrasound and the presence of at least one cardiometabolic criterion. Backward multivariable logistic regression models were applied to define variables independently associated with MASLD.
RESULTS: A total of 302 consecutive participants were included (median age 49 [34-61] years, male sex 58%, median diabetes duration 29 [17-38] years, mean time in range [TIR] 55% ± 16%). MASLD was present in 17% of cases, and 32% had metabolic syndrome (MetS). MetS was significantly more prevalent in the MASLD group (65% vs. 25%, P < .0001). TIR (P = .038) and time below range (TBR) (P = .032) were lower and time above range (TAR) was higher (P = .006), whereas HbA1c did not reach significance (P = .068). No differences were found for the glycaemia risk index. TIR (P = .028), TAR (P = .007), TBR (P = .036), waist circumference (P < .001) and systolic blood pressure (P = .029) were independently associated with MASLD, while sex, age, aspartate aminotransferase/alanine aminotransferase ratio, gamma-glutamyl transferase, high-density lipoprotein cholesterol and triglycerides were not.
CONCLUSIONS: TIR, TAR, TBR, waist circumference and systolic blood pressure were independently associated with MASLD.
摘要：
目的：探讨1型糖尿病(T1D)中连续血糖监测(CGM)与代谢功能障碍相关的脂肪变性肝病(MASLD)的关系。
方法：一项收集人体测量学数据的横断面研究，使用CGM设备对患有T1D的成人进行了肾小球和MASLD。通过腹部超声和至少一个心脏代谢标准的存在来评估MASLD。应用反向多变量逻辑回归模型来定义与MASLD独立相关的变量。
结果：共纳入302名连续参与者（中位年龄49[34-61]岁，男性58%,中位糖尿病病程29[17-38]年，范围内的平均时间[TIR]55%±16%)。MASLD出现在17%的病例中，32%患有代谢综合征(MetS)。MetS在MASLD组中明显更普遍（65%vs.25%,P<.0001)。TIR（P=.038）和低于范围的时间（TBR）（P=.032）较低，高于范围的时间（TAR）较高（P=.006），而HbA1c没有达到显著性（P=0.068）。血糖风险指数没有差异。TIR（P=.028），焦油（P=.007），TBR（P=.036），腰围（P<.001）和收缩压（P=.029）与MASLD独立相关，而性爱,年龄,天冬氨酸转氨酶/丙氨酸转氨酶比值,γ-谷氨酰转移酶，高密度脂蛋白胆固醇和甘油三酯没有。
结论：TIR，TAR,TBR,腰围和收缩压与MASLD独立相关。
方法：一项收集人体测量学数据的横断面研究，使用CGM设备对患有T1D的成人进行了肾小球和MASLD。通过腹部超声和至少一个心脏代谢标准的存在来评估MASLD。应用反向多变量逻辑回归模型来定义与MASLD独立相关的变量。
结果：共纳入302名连续参与者（中位年龄49[34-61]岁，男性58%,中位糖尿病病程29[17-38]年，范围内的平均时间[TIR]55%±16%)。MASLD出现在17%的病例中，32%患有代谢综合征(MetS)。MetS在MASLD组中明显更普遍（65%vs.25%,P<.0001)。TIR（P=.038）和低于范围的时间（TBR）（P=.032）较低，高于范围的时间（TAR）较高（P=.006），而HbA1c没有达到显著性（P=0.068）。血糖风险指数没有差异。TIR（P=.028），焦油（P=.007），TBR（P=.036），腰围（P<.001）和收缩压（P=.029）与MASLD独立相关，而性爱,年龄,天冬氨酸转氨酶/丙氨酸转氨酶比值,γ-谷氨酰转移酶，高密度脂蛋白胆固醇和甘油三酯没有。
结论：TIR，TAR,TBR,腰围和收缩压与MASLD独立相关。
