PDF(Pubmed)
Abstract：
A marine-derived fungal strain, Aspergillus sp. ITBBc1, was isolated from coral collected from the South China Sea in Hainan province. Intensive chemical investigation of the fermentation extract of this strain afforded four new secondary metabolites (1-4), named megastigmanones A-C and prenylterphenyllin H, along with four known compounds (5-8). Their structures were elucidated by extensive spectroscopic analysis including one-and two-dimensional (1D and 2D) NMR spectroscopy and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). The modified Mosher\'s method was undertaken to determine the absolute configurations of new compounds. The phytotoxic activity test showed that compounds 6-8 exhibited significant antagonistic activity against the germination of Triticum aestivum L. and Oryza sativa L. seeds with a dose-dependent relationship.
摘要：
一种海洋真菌菌株,曲霉属。ITBBc1是从海南省南中国海收集的珊瑚中分离出来的。对该菌株的发酵提取物进行了深入的化学研究，提供了四种新的次级代谢产物（1-4），命名为甲磺酸甲-C和异戊烯基对苯苷H，连同四个已知的化合物(5-8)。通过广泛的光谱分析（包括一维和二维（1D和2D）NMR光谱和高分辨率电喷雾电离质谱（HR-ESI-MS））阐明了它们的结构。采用改进的Mosher方法来确定新化合物的绝对构型。植物毒性试验表明，化合物6-8对小麦和水稻种子萌发具有明显的拮抗活性，呈剂量依赖关系。
