Abstract：
BACKGROUND Urogenital bacterial infections have a high incidence in humans. The most frequent cause of infections of the urogenital tract is gram-negative bacteria. Antibiotics are very effective in curing infectious diseases but they are accompanied by health complications. Probiotics are live microorganisms that are believed to confer a beneficial effect on human health when consumed in adequate amounts. This study aimed to compare outcomes from antibiotic treatment with and without the use of probiotics in 897 patients with lower urogenital tract infections, including cystitis, urethritis, prostatitis, and vulvovaginitis. MATERIAL AND METHODS A total of 897 patients aged 18 to 55 years were included in this research. Patients were divided into an intervention group including 460 patients (254 women, 206 men) and a comparison group including 437 patients (240 women, 197 men). The probiotics received by patients were capsules of ProBalans®. The diagnosis of cystitis, urethritis, prostatitis, vulvovaginitis, and sexually transmitted infection was done using several tests, and antibiotics were used for treatment. Qualitative data were analyzed using the chi-square or Fisher exact test. RESULTS We found a significant difference regarding patients\' impressions of improvement after therapy between patients in the intervention group and the comparison group. CONCLUSIONS Use of probiotics together with antibiotics in the treatment of urogenital tract infection can help to reduce the adverse effects of antibiotics, increase the efficiency of antibiotic therapy, and reduce bacterial resistance to antibiotics. However, further research is needed to confirm these potential health benefits.
摘要：
背景技术泌尿生殖系统细菌感染在人类中具有高发病率。泌尿生殖道感染的最常见原因是革兰氏阴性细菌。抗生素在治疗传染病方面非常有效，但它们伴有健康并发症。益生菌是活的微生物,其被认为在以足量食用时对人类健康具有有益作用。这项研究旨在比较897例泌尿生殖道感染患者使用和不使用益生菌的抗生素治疗结果。包括膀胱炎,尿道炎，前列腺炎,和外阴阴道炎.材料与方法本研究共纳入897例患者，年龄在18至55岁之间。将患者分为干预组，其中包括460名患者（254名妇女，206名男性）和包括437名患者（240名女性，197名男子）。患者接受的益生菌是ProBalans®的胶囊。膀胱炎的诊断,尿道炎，前列腺炎,外阴阴道炎,性传播感染是用几个测试来完成的，抗生素用于治疗。使用卡方或Fisher精确检验分析定性数据。结果我们发现干预组和对照组患者治疗后改善的印象存在显着差异。结论益生菌联合抗菌药物治疗泌尿生殖道感染有助于降低抗菌药物的不良反应。提高抗生素治疗的效率，减少细菌对抗生素的耐药性。然而,需要进一步的研究来证实这些潜在的健康益处.
